Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2985849..2986474 Replicon chromosome
Accession NZ_CP067232
Organism Escherichia coli strain SBF45

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JJB20_RS14155 Protein ID WP_000911330.1
Coordinates 2986076..2986474 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag JJB20_RS14150 Protein ID WP_000450524.1
Coordinates 2985849..2986076 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB20_RS14125 (2981652) 2981652..2982122 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
JJB20_RS14130 (2982122) 2982122..2982694 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
JJB20_RS14135 (2982840) 2982840..2983718 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
JJB20_RS14140 (2983735) 2983735..2984769 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
JJB20_RS14145 (2984982) 2984982..2985695 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
JJB20_RS14150 (2985849) 2985849..2986076 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
JJB20_RS14155 (2986076) 2986076..2986474 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
JJB20_RS14160 (2986621) 2986621..2987484 + 864 WP_001267498.1 neutral zinc metallopeptidase -
JJB20_RS14165 (2987499) 2987499..2989514 + 2016 WP_032197281.1 tRNA cytosine(34) acetyltransferase TmcA -
JJB20_RS14170 (2989588) 2989588..2990286 + 699 WP_000679823.1 esterase -
JJB20_RS14175 (2990396) 2990396..2990596 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T185793 WP_000911330.1 NZ_CP067232:2986076-2986474 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T185793 NZ_CP089031:c2222691-2222584 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT185793 WP_000450524.1 NZ_CP067232:2985849-2986076 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT185793 NZ_CP089031:2222744-2222805 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References