Detailed information of TA system TA185782

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 66020..66684
• Replicon: plasmid unnamed1
• Accession: NZ_CP067226
• Organism: Paracoccus sp. MC1862

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JGR78_RS16650
• Protein ID: WP_182806289.1
• Coordinates: 66020..66427 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JGR78_RS16655
• Protein ID: WP_182806073.1
• Coordinates: 66424..66684 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JGR78_RS16635	61161..63140	-	1980	WP_182806162.1	PhoX family phosphatase	-
JGR78_RS16640	63478..64392	+	915	Protein_59	transposase	-
JGR78_RS16650	66020..66427	-	408	WP_182806289.1	type II toxin-antitoxin system VapC family toxin	Toxin
JGR78_RS16655	66424..66684	-	261	WP_182806073.1	antitoxin	Antitoxin
JGR78_RS16660	66750..66935	-	186	WP_182806301.1	WGR domain-containing protein	-
JGR78_RS16665	67061..67633	-	573	WP_200559529.1	recombinase family protein	-
JGR78_RS16670	68045..69652	+	1608	WP_182806134.1	AIPR family protein	-
JGR78_RS16675	70024..71295	+	1272	WP_182806136.1	low temperature requirement protein A	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..113686	113686

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-126)

Antitoxin

• SpoVT-AbrB domain (8-44)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 14709.80 Da
• Isoelectric Point: 5.2171

>T185782 WP_182806289.1 NZ_CP067226:c66427-66020 [Paracoccus sp. MC1862]
MIRRLLDTNVVIALVGRRSAELFRRVEASEPGSLAISSIVAHELWYGAYRSQKVAFNLETLRLLFADLAIVDLDPEDARA
AGEIRAELARQGTPIGPYDVLIAGQAKARSLTLVTNNTGEFSRVAGLSLEDWTAA

Nucleotide

• Length: 408 bp

>T185782 NZ_CP089030:c58138-57827 [Klebsiella pneumoniae]
ATGCACGTAATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAAGCGATATCCCAACGATTCGTTAGCCATTCGGGCGTTGTA
CCGCTTAGTGCGCGAGACGGACTTCTCTTCTCCAGCTGAGATGCTAACTCTGATACCGAGCCTGGATAATTTTAAGTACA
GGAATAAGTGGTGGGTTTTGGATGTAGGGGGCAACAACTTAAGGGTTATCGCCTATATCAATTTCGTAAATAAGCGCTTC
TACGTGAAGCACATCGCAACCCACGCTGATTACGACAAGTTGACCCGCTATTACAGGGAGAACAAAGAATGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9717.90 Da
• Isoelectric Point: 5.7066

>AT185782 WP_182806073.1 NZ_CP067226:c66684-66424 [Paracoccus sp. MC1862]
MPHIAKVFRSGNSQAVRLPKDFRLEASEVEISREGDALILRPKLATDRPWASLHAAVERGFSEDFLTSGREQPAEQQRPD
LDQLFS

Nucleotide

• Length: 261 bp

>AT185782 NZ_CP089030:c57830-57411 [Klebsiella pneumoniae]
ATGATTACCGACACTGCAAAAGCCATTGAAGCAACCAAACAACTCGTAGCTGCCGTCCCCTTCCTAGGGGGCAGTTCTTC
CGAGAGCGATTACCGCGAAGCGATGGAGCTGGTGGATTATCTGATCGAGAACGACGACGAGAACCCACTTATTGACTTCC
TGGCGAGTAAGATTGCCGACTATGAAGATAACAGCCCTCGTTTCGCTGAGTTCAACAAAGCTATTGCTGAAATACCAGTC
GGCGTTGCACTTCTGCGAACCCTGATTGACCAGCACAAGCTGTCTTATTCAGACCTTAAGGATGAGATCGGATCTAAATC
ATTGGTCAGCCAAATCCTGTCAGGGCAGCGCTCTTTGACCATCACTCACATAAAAGCTCTTTCCGCGCGCTTCGGTGTAA
AACCTGAGTGGTTCCTATAA