Detailed information of TA system TA185781

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2576786..2577450
• Replicon: chromosome
• Accession: NZ_CP067225
• Organism: Paracoccus sp. MC1862

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JGR78_RS12665
• Protein ID: WP_182806075.1
• Coordinates: 2576786..2577193 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JGR78_RS12670
• Protein ID: WP_182806073.1
• Coordinates: 2577190..2577450 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JGR78_RS12645	2572416..2572559	+	144	WP_182793555.1	hypothetical protein	-
JGR78_RS12650	2573136..2574251	-	1116	WP_200559332.1	asparaginase	-
JGR78_RS12655	2574400..2575651	+	1252	Protein_2488	IS3 family transposase	-
JGR78_RS12660	2575715..2576359	+	645	WP_182793556.1	hypothetical protein	-
JGR78_RS12665	2576786..2577193	-	408	WP_182806075.1	type II toxin-antitoxin system VapC family toxin	Toxin
JGR78_RS12670	2577190..2577450	-	261	WP_182806073.1	antitoxin	Antitoxin
JGR78_RS12675	2577516..2577701	-	186	WP_182806301.1	WGR domain-containing protein	-
JGR78_RS12680	2577827..2578399	-	573	WP_200559333.1	recombinase family protein	-
JGR78_RS12685	2578873..2579482	+	610	Protein_2494	IS481 family transposase	-
JGR78_RS12690	2579694..2580977	-	1284	WP_200559324.1	IS110 family transposase	-
JGR78_RS12695	2581085..2581294	-	210	WP_182806145.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	2574555..2580977	6422

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-126)

Antitoxin

• SpoVT-AbrB domain (8-44)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 14737.89 Da
• Isoelectric Point: 5.1976

>T185781 WP_182806075.1 NZ_CP067225:c2577193-2576786 [Paracoccus sp. MC1862]
MIRHLLDTNVVIALVGRRSAELLRRVEASEPGSLAISSIVAHELWYGAYRSQKVAFNLETLRLLFADLAIIDLDPEDARA
AGEIRVELARQGTPIGPYDVLIAGQAKARNLTLVTNNIGEFSRVAGLSLEDWTAA

Nucleotide

• Length: 408 bp

>T185781 NZ_CP089029:53243-53548 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGACGACAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGGCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9717.90 Da
• Isoelectric Point: 5.7066

>AT185781 WP_182806073.1 NZ_CP067225:c2577450-2577190 [Paracoccus sp. MC1862]
MPHIAKVFRSGNSQAVRLPKDFRLEASEVEISREGDALILRPKLATDRPWASLHAAVERGFSEDFLTSGREQPAEQQRPD
LDQLFS

Nucleotide

• Length: 261 bp

>AT185781 NZ_CP089029:53023-53241 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA