Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 124637..125249 Replicon plasmid p296221
Accession NZ_CP067170
Organism Paracoccus aestuarii strain DSM 19484

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JHW48_RS16190 Protein ID WP_119886392.1
Coordinates 124854..125249 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JHW48_RS16185 Protein ID WP_119886406.1
Coordinates 124637..124864 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JHW48_RS16170 (JHW48_16090) 119974..121677 - 1704 WP_119886395.1 potassium-transporting ATPase subunit KdpA -
JHW48_RS16175 (JHW48_16100) 122222..122638 + 417 WP_119886393.1 response regulator -
JHW48_RS16180 (JHW48_16105) 122753..124096 - 1344 WP_240637857.1 PAS domain-containing protein -
JHW48_RS16185 (JHW48_16110) 124637..124864 + 228 WP_119886406.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JHW48_RS16190 (JHW48_16115) 124854..125249 + 396 WP_119886392.1 PIN domain-containing protein Toxin
JHW48_RS16195 (JHW48_16120) 126443..126829 - 387 WP_147388097.1 hypothetical protein -
JHW48_RS16200 (JHW48_16125) 126829..127344 - 516 WP_119886390.1 hypothetical protein -
JHW48_RS16205 (JHW48_16130) 127383..128444 - 1062 WP_272835886.1 hypothetical protein -
JHW48_RS16210 (JHW48_16135) 128789..129049 + 261 WP_119887966.1 helix-turn-helix transcriptional regulator -
JHW48_RS16215 (JHW48_16140) 129182..129427 - 246 WP_119887967.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..296221 296221


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-114)

Antitoxin

SpoVT-AbrB domain

(5-46)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14310.46 Da        Isoelectric Point: 4.4227

>T185779 WP_119886392.1 NZ_CP067170:124854-125249 [Paracoccus aestuarii]
MSVEFVDTNVILYLLDDGPKADRAEAILAQGPRISVQVLNEAMVNCRRKAGMDWNDTASFLAGVRALCPVEDLTLRTHDV
GRALAERYGFSVYDAMIVAAALIAGCETLWTEDMHAGLLVEGQLRLVNPFA

Download         Length: 396 bp

>T185779 NZ_CP089024:c5385534-5385151 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTTGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGGTTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8541.81 Da        Isoelectric Point: 10.6439

>AT185779 WP_119886406.1 NZ_CP067170:124637-124864 [Paracoccus aestuarii]
MQVAKWGNSLAVRLPAELVRDMGLKEGDQIDLLPDDGPLRIRRLPRADEVLDGLRRFRGRLPASERLSRDAAHER

Download         Length: 228 bp

>AT185779 NZ_CP089024:c5385776-5385534 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References