Detailed information of TA system TA185778

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-Phd
• Location: 5366..6027
• Replicon: plasmid p296221
• Accession: NZ_CP067170
• Organism: Paracoccus aestuarii strain DSM 19484

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JHW48_RS15665
• Protein ID: WP_119886962.1
• Coordinates: 5366..5779 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JHW48_RS15670
• Protein ID: WP_119886961.1
• Coordinates: 5779..6027 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JHW48_RS15635 (JHW48_15570)	1765..2253	+	489	WP_119887100.1	DUF892 family protein	-
JHW48_RS15640 (JHW48_15575)	2275..3099	+	825	WP_119887099.1	manganese catalase family protein	-
JHW48_RS15645 (JHW48_15580)	3199..3945	+	747	WP_272835882.1	DUF2243 domain-containing protein	-
JHW48_RS15650 (JHW48_15585)	4029..4886	+	858	WP_119886964.1	SDR family oxidoreductase	-
JHW48_RS15655 (JHW48_15590)	5012..5191	+	180	WP_119886963.1	hypothetical protein	-
JHW48_RS15660 (JHW48_15595)	5209..5364	+	156	WP_170152327.1	hypothetical protein	-
JHW48_RS15665 (JHW48_15600)	5366..5779	-	414	WP_119886962.1	type II toxin-antitoxin system VapC family toxin	Toxin
JHW48_RS15670 (JHW48_15605)	5779..6027	-	249	WP_119886961.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JHW48_RS15675 (JHW48_15610)	6106..7980	-	1875	WP_119886960.1	pyrroloquinoline quinone-dependent dehydrogenase	-
JHW48_RS15680 (JHW48_15615)	7977..8303	-	327	WP_119886959.1	hypothetical protein	-
JHW48_RS15685 (JHW48_15620)	8463..8636	+	174	WP_170152326.1	hypothetical protein	-
JHW48_RS15690 (JHW48_15625)	8957..9841	+	885	WP_119886958.1	AraC family transcriptional regulator	-
JHW48_RS15695 (JHW48_15630)	9942..10844	+	903	WP_272835892.1	ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..296221	296221

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-118)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-48)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15117.31 Da
• Isoelectric Point: 5.1267

>T185778 WP_119886962.1 NZ_CP067170:c5779-5366 [Paracoccus aestuarii]
MWLIDTNVISALRRPERAPAVARWLRGQDPDALFLSVVTLGEIERGITQQDSRNPDFARDLRLWLQRTELLFADRILPFD
PPAARIWGQLSARIGHPGADLMIAASALSRGMTVVTGNVDDFTPSGVPVLNPFGDVT

Nucleotide

• Length: 414 bp

>T185778 NZ_CP089024:c4914177-4913893 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8837.00 Da
• Isoelectric Point: 10.0850

>AT185778 WP_119886961.1 NZ_CP067170:c6027-5779 [Paracoccus aestuarii]
MWNLQDAKTRFSTVVADALAGRPQHVTRRGKPAVVVLSEADYAQLKAAAQASRESFVDHLLAFPAQDTALSRASAAPRDV
AF

Nucleotide

• Length: 249 bp

>AT185778 NZ_CP089024:c4914409-4914167 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA