Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RHH
Location 216479..217035 Replicon plasmid p242883
Accession NZ_CP067141
Organism Paracoccus saliphilus strain DSM 18447

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag JHX88_RS22080 Protein ID WP_272848303.1
Coordinates 216479..216796 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JHX88_RS22085 Protein ID WP_272848304.1
Coordinates 216784..217035 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JHX88_RS22045 (JHX88_21985) 211597..211878 - 282 WP_076528664.1 helix-turn-helix domain-containing protein -
JHX88_RS22050 (JHX88_21990) 212020..212508 - 489 WP_272848302.1 DUF2285 domain-containing protein -
JHX88_RS22055 (JHX88_21995) 212594..212797 - 204 WP_076528668.1 DUF6499 domain-containing protein -
JHX88_RS22060 (JHX88_22000) 212907..213185 - 279 WP_076528670.1 DUF2285 domain-containing protein -
JHX88_RS22065 (JHX88_22005) 213593..213994 - 402 WP_076528672.1 single-stranded DNA-binding protein -
JHX88_RS22070 (JHX88_22010) 214696..215112 - 417 WP_076528674.1 hypothetical protein -
JHX88_RS22075 (JHX88_22015) 215339..216373 + 1035 WP_076528687.1 nuclease -
JHX88_RS22080 (JHX88_22020) 216479..216796 - 318 WP_272848303.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JHX88_RS22085 (JHX88_22025) 216784..217035 - 252 WP_272848304.1 ribbon-helix-helix protein, CopG family Antitoxin
JHX88_RS22090 (JHX88_22030) 217112..218023 - 912 WP_084203319.1 zincin-like metallopeptidase domain-containing protein -
JHX88_RS22095 218305..218430 - 126 WP_272848305.1 hypothetical protein -
JHX88_RS22100 (JHX88_22035) 218705..218944 - 240 WP_141225941.1 hypothetical protein -
JHX88_RS22105 (JHX88_22040) 218998..219183 + 186 WP_076528678.1 hypothetical protein -
JHX88_RS22110 219237..219369 + 133 Protein_217 IS110 family transposase -
JHX88_RS22115 (JHX88_22045) 219855..220418 + 564 WP_141225942.1 dTDP-4-dehydrorhamnose 3,5-epimerase -
JHX88_RS22120 (JHX88_22050) 220415..221452 + 1038 WP_076528680.1 dTDP-glucose 4,6-dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - katB / glf / glf 1..242883 242883


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-93)

Antitoxin

Ribbon-helix-helix protein, CopG

(17-44)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11575.14 Da        Isoelectric Point: 5.1056

>T185776 WP_272848303.1 NZ_CP067141:c216796-216479 [Paracoccus saliphilus]
MDALKRLGIAEPAARDLAHIVDYIALDNPASAENVYREIVQAAERLPEFPALGRPGRHPETRELSITGLPYLIVYEVGVD
TVTILAVFHTSRDLSQAPHDRMQGS

Download         Length: 318 bp

>T185776 NZ_CP089024:4157848-4158066 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9257.45 Da        Isoelectric Point: 5.8395

>AT185776 WP_272848304.1 NZ_CP067141:c217035-216784 [Paracoccus saliphilus]
MAQRTASEPITIRTAKVAEIDALANAMDRSRNYIVNQAIERYLEANAWQMERIEEGIAASREGKVVPADEVFAGIAARHG
WTR

Download         Length: 252 bp

>AT185776 NZ_CP089024:4157447-4157821 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References