Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 80757..81318 Replicon plasmid p242883
Accession NZ_CP067141
Organism Paracoccus saliphilus strain DSM 18447

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag JHX88_RS21375 Protein ID WP_076526872.1
Coordinates 80757..81032 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JHX88_RS21380 Protein ID WP_076526873.1
Coordinates 81025..81318 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JHX88_RS21345 (JHX88_21300) 77039..77236 - 198 WP_141225856.1 hypothetical protein -
JHX88_RS21350 (JHX88_21305) 77369..77524 + 156 Protein_65 IS110 family transposase -
JHX88_RS21355 (JHX88_21310) 78201..78482 + 282 WP_076526868.1 DUF3892 domain-containing protein -
JHX88_RS21360 (JHX88_21315) 78980..79519 - 540 WP_076526869.1 MFS transporter -
JHX88_RS21365 (JHX88_21320) 79584..79969 + 386 Protein_68 IS200/IS605 family transposase -
JHX88_RS21370 (JHX88_21325) 80151..80363 + 213 WP_076526870.1 hypothetical protein -
JHX88_RS21375 (JHX88_21330) 80757..81032 - 276 WP_076526872.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
JHX88_RS21380 (JHX88_21335) 81025..81318 - 294 WP_076526873.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JHX88_RS21385 (JHX88_21340) 81928..82281 + 354 WP_076526874.1 DUF1636 domain-containing protein -
JHX88_RS21390 (JHX88_21345) 82285..83331 + 1047 WP_076526875.1 cobalamin biosynthesis protein CobW -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - katB / glf / glf 1..242883 242883


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-54)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10058.61 Da        Isoelectric Point: 4.7769

>T185775 WP_076526872.1 NZ_CP067141:c81032-80757 [Paracoccus saliphilus]
VPEVEWKAPAVADLVAIVEYISDDNPDAALALLEEIQGKVAQLPAHPKRCRPDRVEGTRELMVRPNYIAVYAETAATVTV
LRVLHAAQMWP

Download         Length: 276 bp

>T185775 NZ_CP089024:c2846108-2844786 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGAGGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCTCTCTCACTGCCGCTGCAGTATGGCAATATCACGG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAA
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTTACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCGGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTTTCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10175.59 Da        Isoelectric Point: 5.6283

>AT185775 WP_076526873.1 NZ_CP067141:c81318-81025 [Paracoccus saliphilus]
MPAQTSMLHVRVDDQLKAQAADALSGVGLTLSDAVRILLTRVAAEGGLPAGLTADPDAYDAWFRAKVQEALADLRPATPH
DQVMQGAGALIDGKRRA

Download         Length: 294 bp

>AT185775 NZ_CP089024:c2846374-2846108 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References