Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 10303..11390 Replicon plasmid p90204
Accession NZ_CP067137
Organism Paracoccus fistulariae strain KCTC 22803

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag JHX87_RS17970 Protein ID WP_271886982.1
Coordinates 10764..11390 (+) Length 209 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag JHX87_RS17965 Protein ID WP_271886981.1
Coordinates 10303..10767 (+) Length 155 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JHX87_RS17945 (JHX87_17930) 6628..7356 + 729 WP_271886807.1 hypothetical protein -
JHX87_RS17950 (JHX87_17935) 7458..7859 + 402 WP_271886806.1 hypothetical protein -
JHX87_RS17955 (JHX87_17940) 8109..9041 - 933 WP_272833967.1 IS110 family transposase -
JHX87_RS17960 (JHX87_17945) 9344..10127 - 784 Protein_7 IS3 family transposase -
JHX87_RS17965 (JHX87_17950) 10303..10767 + 465 WP_271886981.1 helix-turn-helix domain-containing protein Antitoxin
JHX87_RS17970 (JHX87_17955) 10764..11390 + 627 WP_271886982.1 PIN domain-containing protein Toxin
JHX87_RS17975 (JHX87_17960) 11335..12549 + 1215 WP_272833674.1 IS256 family transposase -
JHX87_RS17980 (JHX87_17965) 12686..12928 + 243 WP_272833955.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
JHX87_RS17985 (JHX87_17970) 12925..13299 + 375 WP_271886934.1 type II toxin-antitoxin system VapC family toxin -
JHX87_RS17990 (JHX87_17975) 13691..14077 + 387 Protein_13 IS21 family transposase -
JHX87_RS17995 (JHX87_17980) 14145..14387 + 243 Protein_14 integrase core domain-containing protein -
JHX87_RS18000 (JHX87_17985) 14384..15373 - 990 WP_271886933.1 inositol 2-dehydrogenase -
JHX87_RS18005 (JHX87_17990) 15375..16205 - 831 WP_271886932.1 class II fructose-bisphosphate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..90204 90204


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(11-115)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 209 a.a.        Molecular weight: 22718.78 Da        Isoelectric Point: 4.7216

>T185774 WP_271886982.1 NZ_CP067137:10764-11390 [Paracoccus fistulariae]
MSRYTDRFTALLDACVLGGALRRNMLLSLAEAGLFRPRWSSRILDETQKAIAQIIKGATDGSRQRAAIEAAFPEAMVTGY
EIFEDRLALPDPDDNHVLAAAIATSASVIVTDNLADFPFAVLDAHAIQAISADDFIADTIELDPSEAILALRRMRERFKN
PALDVAALIHKSEAQGLLQVGSMLPERSKDHDDFERTAGRAAERLQTA

Download         Length: 627 bp

>T185774 NZ_CP089024:2085426-2085528 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 155 a.a.        Molecular weight: 17023.46 Da        Isoelectric Point: 4.9044

>AT185774 WP_271886981.1 NZ_CP067137:10303-10767 [Paracoccus fistulariae]
MNALRKEAFFDRLPDEVEIKNAEQLRTIVASQIKEGEPTKLSLALEGGEVQTVTLAPALTASLLEVLRLVSSGRGFRMIP
VESELTTQQAADLLNVSRPFLVKLLEEGKIPFAKTGRHRRVRADDLFAYKNERDASRSDTLSDLAAMDAEEGLV

Download         Length: 465 bp

>AT185774 NZ_CP089024:c2085535-2085390 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References