Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 496111..496916 Replicon chromosome
Accession NZ_CP067124
Organism Paracoccus alcaliphilus strain TK 1015 = DSM 8512

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag JHW40_RS02615 Protein ID WP_211657400.1
Coordinates 496111..496626 (-) Length 172 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag JHW40_RS02620 Protein ID WP_090616586.1
Coordinates 496623..496916 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JHW40_RS02590 (JHW40_02600) 491463..492407 + 945 WP_090616577.1 phage tail tube protein -
JHW40_RS02595 (JHW40_02605) 492411..492848 + 438 WP_090616578.1 hypothetical protein -
JHW40_RS02600 (JHW40_02610) 492947..493081 + 135 WP_272849035.1 hypothetical protein -
JHW40_RS02605 (JHW40_02615) 493074..495482 + 2409 Protein_514 tape measure protein -
JHW40_RS02610 (JHW40_02620) 495482..496108 + 627 WP_090616582.1 DUF2460 domain-containing protein -
JHW40_RS02615 (JHW40_02625) 496111..496626 - 516 WP_211657400.1 GNAT family N-acetyltransferase Toxin
JHW40_RS02620 (JHW40_02630) 496623..496916 - 294 WP_090616586.1 DUF1778 domain-containing protein Antitoxin
JHW40_RS02625 (JHW40_02635) 496995..497879 + 885 WP_090616588.1 DUF2163 domain-containing protein -
JHW40_RS02630 (JHW40_02640) 497876..498337 + 462 WP_090616590.1 NlpC/P60 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 471492..527037 55545


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(49-148)

Antitoxin

Vibrio phage ICP1, Orf50

(12-96)


Sequences

Toxin        


Download         Length: 172 a.a.        Molecular weight: 18249.15 Da        Isoelectric Point: 10.3323

>T185772 WP_211657400.1 NZ_CP067124:c496626-496111 [Paracoccus alcaliphilus]
MTQGMQPLRAPVPLSDDHLIDGFASGATTLDTWLKRKARANQVSGASRAYVLCRGQRAVGFYALAAGSVSHDLAPRRLRQ
NMPDPIPVIVLGRLAVDVSEQGNGLGRALLRDAVLRITAAAHEVGIAAILVHALNERAKAFYVGAGFAETVLEPMTLFLR
IKDARALIGEG

Download         Length: 516 bp

>T185772 NZ_CP089024:734268-734753 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCGCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATTCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10781.27 Da        Isoelectric Point: 6.3598

>AT185772 WP_090616586.1 NZ_CP067124:c496916-496623 [Paracoccus alcaliphilus]
MAAVTSKEDAPRRSLINLRVTPRDRDLIDRAAAALGKNRSEFMMEASRQAAEDALLDRTAFRLDAEQFSAFMAQLDAPPA
PNERLGKLLATPAPWER

Download         Length: 294 bp

>AT185772 NZ_CP089024:733978-734271 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References