185771

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ParE-CopA/ParE-RHH
Location 490362..490924 Replicon chromosome
Accession NZ_CP067124
Organism Paracoccus alcaliphilus strain TK 1015 = DSM 8512

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag JHW40_RS02575 Protein ID WP_090616571.1
Coordinates 490362..490652 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name copA Uniprot ID -
Locus tag JHW40_RS02580 Protein ID WP_090616573.1
Coordinates 490640..490924 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JHW40_RS02550 (JHW40_02560) 486515..487840 + 1326 WP_090616562.1 S49 family peptidase -
JHW40_RS02555 (JHW40_02565) 487936..488316 + 381 WP_090616564.1 head decoration protein -
JHW40_RS02560 (JHW40_02570) 488374..489396 + 1023 WP_090616565.1 major capsid protein -
JHW40_RS02565 (JHW40_02575) 489409..489723 + 315 WP_090616567.1 hypothetical protein -
JHW40_RS02570 (JHW40_02580) 489720..490346 + 627 WP_090616569.1 DUF6441 family protein -
JHW40_RS02575 (JHW40_02585) 490362..490652 - 291 WP_090616571.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JHW40_RS02580 (JHW40_02590) 490640..490924 - 285 WP_090616573.1 ribbon-helix-helix protein, CopG family Antitoxin
JHW40_RS02585 (JHW40_02595) 491014..491436 + 423 WP_090616575.1 acyl-CoA transferase -
JHW40_RS02590 (JHW40_02600) 491463..492407 + 945 WP_090616577.1 phage tail tube protein -
JHW40_RS02595 (JHW40_02605) 492411..492848 + 438 WP_090616578.1 hypothetical protein -
JHW40_RS02600 (JHW40_02610) 492947..493081 + 135 WP_272849035.1 hypothetical protein -
JHW40_RS02605 (JHW40_02615) 493074..495482 + 2409 Protein_514 tape measure protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 471492..527037 55545


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(8-44)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11009.50 Da        Isoelectric Point: 5.8700

>T185771 WP_090616571.1 NZ_CP067124:c490652-490362 [Paracoccus alcaliphilus]
MPQLIWSPAALRDVERLYRFLADKNPDAARRAAKSIREGMNILRDQPGVGRPVEDMEPEFREWLIAFGDSGYVSLYRFDG
ETAVVLAVRHQREAGY

Download         Length: 291 bp

>T185771 NZ_CP089024:330008-330376 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACTGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10828.01 Da        Isoelectric Point: 6.0873

>AT185771 WP_090616573.1 NZ_CP067124:c490924-490640 [Paracoccus alcaliphilus]
MNAVRPVAVKLDQDTRDRLKRLADAKDRSTHWMLREAVSQFVEREEKREAFRQAGLQAWQEYQATGKHVTHDEADAWLAR
LEAGEDAAAPECHN

Download         Length: 285 bp

>AT185771 NZ_CP089024:329790-330011 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References