Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 4098582..4099186 Replicon chromosome
Accession NZ_CP067098
Organism Pseudomonas sp. SW-3

Toxin (Protein)


Gene name PumA Uniprot ID A0A855KA05
Locus tag JIO00_RS18325 Protein ID WP_010455649.1
Coordinates 4098582..4098875 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A024EJX4
Locus tag JIO00_RS18330 Protein ID WP_010455651.1
Coordinates 4098878..4099186 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JIO00_RS18305 4093671..4094360 + 690 WP_154501212.1 N-acetyltransferase -
JIO00_RS18310 4094365..4095582 + 1218 WP_010455642.1 GNAT family N-acetyltransferase -
JIO00_RS18315 4095554..4096345 + 792 WP_042932752.1 ChbG/HpnK family deacetylase -
JIO00_RS18320 4096461..4097153 + 693 WP_077749045.1 N-acetyltransferase -
JIO00_RS18325 4098582..4098875 + 294 WP_010455649.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JIO00_RS18330 4098878..4099186 + 309 WP_010455651.1 putative addiction module antidote protein Antitoxin
JIO00_RS18335 4099200..4100012 - 813 WP_200666539.1 class I SAM-dependent methyltransferase -
JIO00_RS18340 4100192..4100578 + 387 WP_083376379.1 hypothetical protein -
JIO00_RS18345 4100582..4102009 - 1428 WP_154501214.1 sigma-54 dependent transcriptional regulator -
JIO00_RS18350 4101978..4103471 - 1494 WP_200666541.1 HAMP domain-containing histidine kinase -
JIO00_RS18355 4103575..4103814 - 240 Protein_3629 electron transporter SenC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(5-96)

Antitoxin

Uncharacterized protein HI1420

(4-93)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10646.39 Da        Isoelectric Point: 10.8628

>T185753 WP_010455649.1 NZ_CP067098:4098582-4098875 [Pseudomonas sp. SW-3]
MNYIVQQTMIFVAWHASVRDLRAKIAIARRIDRASAGNLGDIKPVGDGVSEMRVDVGAGYRVYFTLRNSVVIVLLAGGDK
SSQTADIRRAKKLAKEV

Download         Length: 294 bp

>T185753 NZ_CP089019:c14266-13916 [Klebsiella pneumoniae]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11043.61 Da        Isoelectric Point: 5.0482

>AT185753 WP_010455651.1 NZ_CP067098:4098878-4099186 [Pseudomonas sp. SW-3]
MSQTLTTFDMAALLDSDEAISEYLSQVLAEGDNEEFLRAIGYVVKARGMTQIAKDSGMGRESLYKAFAPGAKPRFDTVLK
VIHALGIDLCAQPGHSINHSVL

Download         Length: 309 bp

>AT185753 NZ_CP089019:c13911-13609 [Klebsiella pneumoniae]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A855KA05

Antitoxin

Source ID Structure
AlphaFold DB A0A024EJX4

References