Detailed information of TA system TA185752

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 345844..346481
• Replicon: chromosome
• Accession: NZ_CP067098
• Organism: Pseudomonas sp. SW-3

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JIO00_RS01545
• Protein ID: WP_010464625.1
• Coordinates: 345844..346251 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JIO00_RS01550
• Protein ID: WP_083375253.1
• Coordinates: 346251..346481 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JIO00_RS01525	341614..342360	-	747	WP_200667480.1	ABC transporter substrate-binding protein	-
JIO00_RS01530	342374..343147	-	774	WP_007897462.1	ABC transporter ATP-binding protein	-
JIO00_RS01535	343701..345092	+	1392	WP_077747581.1	GABA permease	-
JIO00_RS01540	345438..345764	+	327	WP_010464627.1	hypothetical protein	-
JIO00_RS01545	345844..346251	-	408	WP_010464625.1	tRNA(fMet)-specific endonuclease VapC	Toxin
JIO00_RS01550	346251..346481	-	231	WP_083375253.1	antitoxin	Antitoxin
JIO00_RS01555	346657..347109	-	453	WP_154911946.1	hypothetical protein	-
JIO00_RS01560	347115..347531	-	417	WP_200667481.1	hypothetical protein	-
JIO00_RS01565	347569..348543	-	975	WP_200667482.1	alpha/beta fold hydrolase	-
JIO00_RS01570	348727..349170	-	444	Protein_305	hypothetical protein	-
JIO00_RS01575	349432..349881	+	450	WP_010464612.1	hypothetical protein	-
JIO00_RS01580	349919..350380	-	462	WP_010464610.1	DUF4234 domain-containing protein	-
JIO00_RS01590	350892..351164	-	273	WP_010464608.1	oxidative damage protection protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	326470..346481	20011

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 15067.44 Da
• Isoelectric Point: 6.0845

>T185752 WP_010464625.1 NZ_CP067098:c346251-345844 [Pseudomonas sp. SW-3]
MIKFMLDTNICIFTIKNKPQIVREAFNLHDGQLCISAITLMELIYGAEKSATPEKNLAVIEGFTARLEVFPFDNEAAAHT
GMIRSELAKAGTPIGPYDQMIAGHARSRGLIVVTNNLREFERVPGLRVEDWVHPD

Nucleotide

• Length: 408 bp

>T185752 NZ_CP089017:c6113-5808 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGACGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8710.71 Da
• Isoelectric Point: 4.4720

>AT185752 WP_083375253.1 NZ_CP067098:c346481-346251 [Pseudomonas sp. SW-3]
MEQTTLFMSNRSQAVRLPKAVAMPSDVKRVNVFAIGRARIITPADETWDSWFDGDNVSTDFMTDRQQPADQERESF

Nucleotide

• Length: 231 bp

>AT185752 NZ_CP089017:c6333-6115 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA