Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 920113..920740 Replicon chromosome
Accession NZ_CP067097
Organism Alicyclobacillus cycloheptanicus strain SCH

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag JI721_RS04255 Protein ID WP_274456828.1
Coordinates 920113..920463 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag JI721_RS04260 Protein ID WP_274456829.1
Coordinates 920468..920740 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JI721_RS04235 (JI721_04250) 915884..916102 - 219 WP_274456825.1 DUF2922 domain-containing protein -
JI721_RS04240 (JI721_04255) 916191..916472 - 282 WP_274456826.1 DUF1659 domain-containing protein -
JI721_RS04245 (JI721_04260) 916597..917478 - 882 WP_274456827.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -
JI721_RS04250 (JI721_04265) 917545..918780 - 1236 WP_274457662.1 adenosylhomocysteinase -
JI721_RS04255 (JI721_04270) 920113..920463 - 351 WP_274456828.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JI721_RS04260 (JI721_04275) 920468..920740 - 273 WP_274456829.1 ribbon-helix-helix protein, CopG family Antitoxin
JI721_RS04265 (JI721_04280) 920907..922178 - 1272 WP_274456830.1 alanine racemase -
JI721_RS04270 (JI721_04285) 922356..923342 - 987 WP_274456831.1 outer membrane lipoprotein carrier protein LolA -
JI721_RS04275 (JI721_04290) 923424..924914 - 1491 WP_274456832.1 NAD(P)H-hydrate dehydratase -
JI721_RS04280 (JI721_04295) 925060..925437 - 378 WP_274456833.1 holo-ACP synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12902.96 Da        Isoelectric Point: 5.7117

>T185751 WP_274456828.1 NZ_CP067097:c920463-920113 [Alicyclobacillus cycloheptanicus]
MNVKRGDVFFADLSPVVGSEQGGFRPVLVIQNNIGNRFSPTVIVAAITAQIQKAKLPTHVEIMAEEYGLERDSVILLEQI
RTIDKQRLTDKITHLDARSMKLVDEALQISLGLVDF

Download         Length: 351 bp

>T185751 NZ_CP089014:c5305643-5305260 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10459.99 Da        Isoelectric Point: 8.5175

>AT185751 WP_274456829.1 NZ_CP067097:c920740-920468 [Alicyclobacillus cycloheptanicus]
VSDRKRIVVYLPTQLLEQVDVMAERGRTNRSEVIREAMRQYVTEQRKFEIRNSMQQGYMEMARINLRIASEAFPLEQEAG
GTVERLVSGV

Download         Length: 273 bp

>AT185751 NZ_CP089014:c5305885-5305643 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References