185748

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 261687..262209 Replicon plasmid p1
Accession NZ_CP067094
Organism Klebsiella michiganensis strain B106

Toxin (Protein)


Gene name stbE Uniprot ID A0A7H0EVH6
Locus tag IMZ21_RS29165 Protein ID WP_014839901.1
Coordinates 261925..262209 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A7H0EVH5
Locus tag IMZ21_RS29160 Protein ID WP_014839900.1
Coordinates 261687..261935 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMZ21_RS29135 256865..257221 + 357 WP_017901071.1 hypothetical protein -
IMZ21_RS29140 257595..257993 + 399 WP_014839899.1 H-NS histone family protein -
IMZ21_RS29145 258130..258738 + 609 WP_024266306.1 DUF2913 family protein -
IMZ21_RS29150 259282..259914 + 633 WP_001567369.1 hypothetical protein -
IMZ21_RS29155 259943..261346 - 1404 WP_001567368.1 ISNCY-like element ISKpn21 family transposase -
IMZ21_RS29160 261687..261935 + 249 WP_014839900.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IMZ21_RS29165 261925..262209 + 285 WP_014839901.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IMZ21_RS29170 262400..262876 + 477 WP_042934526.1 hypothetical protein -
IMZ21_RS29175 262882..263559 + 678 WP_042934501.1 hypothetical protein -
IMZ21_RS29180 263576..264295 - 720 WP_042934502.1 cation:proton antiporter -
IMZ21_RS29185 264536..265138 - 603 WP_014839902.1 hypothetical protein -
IMZ21_RS29190 265135..265656 - 522 WP_048336588.1 hypothetical protein -
IMZ21_RS29195 265737..266681 - 945 WP_014839903.1 DsbA family protein -
IMZ21_RS29200 266744..266953 - 210 WP_125316032.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid fosA3 / mph(A) / sul1 / qacE / aadA16 / dfrA27 / ARR-3 / msr(E) / mph(E) / tet(D) - 1..284262 284262
- flank IS/Tn - - 259943..261346 1403


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10866.46 Da        Isoelectric Point: 10.5831

>T185748 WP_014839901.1 NZ_CP067094:261925-262209 [Klebsiella michiganensis]
MTYKLAFNESALKEWKKLGHTIREQFKKKLSERLQNPRVPAAQLHGGKDQYKIKLHGAGYRLVYSVNDEIVTVTVIGVGK
RNNDDIYNATRHRN

Download         Length: 285 bp

>T185748 NZ_CP089014:c4723468-4722935 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9071.29 Da        Isoelectric Point: 3.8832

>AT185748 WP_014839900.1 NZ_CP067094:261687-261935 [Klebsiella michiganensis]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMEMLEDQELGRIADERIGEDRIEVNID
DL

Download         Length: 249 bp

>AT185748 NZ_CP089014:c4723745-4723479 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H0EVH6

Antitoxin

Source ID Structure
AlphaFold DB A0A7H0EVH5

References