Detailed information of TA system TA185747

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 5512423..5513242
• Replicon: chromosome
• Accession: NZ_CP067093
• Organism: Klebsiella michiganensis strain B106

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: -
• Locus tag: IMZ21_RS25995
• Protein ID: WP_004129235.1
• Coordinates: 5512985..5513242 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: A0A2J4V3L3
• Locus tag: IMZ21_RS25990
• Protein ID: WP_049115078.1
• Coordinates: 5512423..5512974 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IMZ21_RS25970	5508059..5508823	+	765	WP_123828438.1	SDR family oxidoreductase	-
IMZ21_RS25975	5508872..5509291	+	420	WP_049115076.1	RbsD/FucU family protein	-
IMZ21_RS25980	5509335..5510381	-	1047	WP_004129248.1	LacI family transcriptional regulator	-
IMZ21_RS25985	5510777..5512405	-	1629	WP_112165897.1	SAM-dependent methyltransferase	-
IMZ21_RS25990	5512423..5512974	-	552	WP_049115078.1	N-acetyltransferase	Antitoxin
IMZ21_RS25995	5512985..5513242	-	258	WP_004129235.1	YjhX family toxin	Toxin
IMZ21_RS26000	5513826..5515010	+	1185	WP_004129234.1	mannonate dehydratase	-
IMZ21_RS26005	5515087..5516562	+	1476	WP_112165899.1	fructuronate reductase	-
IMZ21_RS26010	5516700..5517476	+	777	WP_004129229.1	Uxu operon transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T185747 WP_004129235.1 NZ_CP067093:c5513242-5512985 [Klebsiella michiganensis]
MNLSRQEQRTLHVLAKGGRIAHVRDTSGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T185747 NZ_CP089014:4110880-4111098 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20051.94 Da
• Isoelectric Point: 7.5404

>AT185747 WP_049115078.1 NZ_CP067093:c5512974-5512423 [Klebsiella michiganensis]
MTNHSFTFHVASEGDTDDILNVETRAFGYSKEARLVASLLNDESASPTLSLLARHNGKAVGHILFTRAMFKGEPDSPMMH
ILAPLAVVPEYQGAGVGGALIRHGIEQLKAMGSQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEAHKACWMLQRLSS
QPLGRTGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT185747 NZ_CP089014:4110479-4110853 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A2J4V3L3