Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3775788..3776548 Replicon chromosome
Accession NZ_CP067091
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain ER3625

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag JJB80_RS18360 Protein ID WP_000533909.1
Coordinates 3775788..3776273 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag JJB80_RS18365 Protein ID WP_000965886.1
Coordinates 3776261..3776548 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB80_RS18330 (3770858) 3770858..3771520 + 663 WP_000747548.1 OmpA family lipoprotein -
JJB80_RS18335 (3771739) 3771739..3772713 + 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
JJB80_RS18340 (3772763) 3772763..3773473 - 711 WP_000190524.1 DUF3053 domain-containing protein -
JJB80_RS18345 (3773912) 3773912..3774202 + 291 WP_000455790.1 HTH-type transcriptional regulator -
JJB80_RS18350 (3774491) 3774491..3774703 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
JJB80_RS18355 (3774877) 3774877..3775416 + 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
JJB80_RS18360 (3775788) 3775788..3776273 - 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
JJB80_RS18365 (3776261) 3776261..3776548 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
JJB80_RS18370 (3776726) 3776726..3777193 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
JJB80_RS18375 (3777365) 3777365..3777640 - 276 Protein_3606 IS3 family transposase -
JJB80_RS18380 (3777822) 3777822..3779891 - 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
JJB80_RS18385 (3779901) 3779901..3780812 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
JJB80_RS18390 (3780951) 3780951..3781253 - 303 WP_000605590.1 YsaB family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T185729 WP_000533909.1 NZ_CP067091:c3776273-3775788 [Salmonella enterica subsp. enterica serovar Typhimurium]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T185729 NZ_CP089012:1816958-1817060 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT185729 WP_000965886.1 NZ_CP067091:c3776548-3776261 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT185729 NZ_CP089012:c1817067-1816922 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References