185715

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 1626481..1627003 Replicon chromosome
Accession NZ_CP067091
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain ER3625

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag JJB80_RS07960 Protein ID WP_000221343.1
Coordinates 1626481..1626765 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag JJB80_RS07965 Protein ID WP_000885424.1
Coordinates 1626755..1627003 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB80_RS07940 (1622556) 1622556..1624064 - 1509 WP_000199411.1 FAD-dependent oxidoreductase -
JJB80_RS07945 (1624109) 1624109..1624597 + 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
JJB80_RS07950 (1624790) 1624790..1625869 + 1080 WP_210138940.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
JJB80_RS07955 (1625921) 1625921..1626310 - 390 WP_000194089.1 RidA family protein -
JJB80_RS07960 (1626481) 1626481..1626765 - 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JJB80_RS07965 (1626755) 1626755..1627003 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JJB80_RS07970 (1627155) 1627155..1627370 + 216 WP_000206207.1 hypothetical protein -
JJB80_RS07975 (1627360) 1627360..1627692 + 333 WP_000253154.1 DUF1493 family protein -
JJB80_RS07980 (1627835) 1627835..1628743 + 909 WP_010989018.1 hypothetical protein -
JJB80_RS07985 (1628799) 1628799..1629513 - 715 Protein_1564 helix-turn-helix domain-containing protein -
JJB80_RS07990 (1630321) 1630321..1631787 - 1467 WP_000987828.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T185715 WP_000221343.1 NZ_CP067091:c1626765-1626481 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T185715 NZ_CP089001:4029673-4029891 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT185715 WP_000885424.1 NZ_CP067091:c1627003-1626755 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT185715 NZ_CP089001:4029272-4029646 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References