Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1637144..1637756 Replicon chromosome
Accession NZ_CP067090
Organism Streptococcus pyogenes MGAS10870

Toxin (Protein)


Gene name parE Uniprot ID A0A4Z2JY48
Locus tag C9Q_RS08465 Protein ID WP_002982731.1
Coordinates 1637421..1637756 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A5S4TJ53
Locus tag C9Q_RS08460 Protein ID WP_011055007.1
Coordinates 1637144..1637431 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C9Q_RS08435 (C9Q_08390) 1632366..1633349 - 984 WP_011055003.1 tagatose-bisphosphate aldolase -
C9Q_RS08440 (C9Q_08395) 1633353..1634282 - 930 WP_011055004.1 tagatose-6-phosphate kinase -
C9Q_RS08445 (C9Q_08400) 1634328..1634843 - 516 WP_011055005.1 galactose-6-phosphate isomerase subunit LacB -
C9Q_RS08450 (C9Q_08405) 1634878..1635306 - 429 WP_002982747.1 galactose-6-phosphate isomerase subunit LacA -
C9Q_RS08455 (C9Q_08410) 1635721..1636494 + 774 WP_011055006.1 DeoR/GlpR family DNA-binding transcription regulator -
C9Q_RS08460 (C9Q_08415) 1637144..1637431 + 288 WP_011055007.1 hypothetical protein Antitoxin
C9Q_RS08465 (C9Q_08420) 1637421..1637756 + 336 WP_002982731.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C9Q_RS08470 (C9Q_08425) 1637880..1638894 + 1015 Protein_1610 site-specific integrase -
C9Q_RS08475 (C9Q_08430) 1639026..1639418 - 393 WP_002982716.1 30S ribosomal protein S9 -
C9Q_RS08480 (C9Q_08435) 1639439..1639885 - 447 WP_002982710.1 50S ribosomal protein L13 -
C9Q_RS08485 (C9Q_08440) 1640103..1640309 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
C9Q_RS08490 (C9Q_08445) 1640306..1641004 - 699 WP_011055008.1 hypothetical protein -
C9Q_RS08495 (C9Q_08450) 1641131..1641991 - 861 WP_011055009.1 DegV family protein -
C9Q_RS08500 (C9Q_08455) 1642088..1642606 - 519 WP_011055010.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13145.88 Da        Isoelectric Point: 5.2144

>T185710 WP_002982731.1 NZ_CP067090:1637421-1637756 [Streptococcus pyogenes MGAS10870]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T185710 NZ_CP089001:838365-838775 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10964.59 Da        Isoelectric Point: 5.2318

>AT185710 WP_011055007.1 NZ_CP067090:1637144-1637431 [Streptococcus pyogenes MGAS10870]
MTTVKKNRTVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT185710 NZ_CP089001:838118-838384 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Z2JY48

Antitoxin

Source ID Structure
AlphaFold DB A0A5S4TJ53

References