Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-VagC |
| Location | 550954..551580 | Replicon | chromosome |
| Accession | NZ_CP067089 | ||
| Organism | Breznakiella homolactica strain RmG30 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | JFL75_RS02785 | Protein ID | WP_215625175.1 |
| Coordinates | 551185..551580 (+) | Length | 132 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | JFL75_RS02780 | Protein ID | WP_215625174.1 |
| Coordinates | 550954..551184 (+) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JFL75_RS02735 (JFL75_13020) | 546201..546443 | + | 243 | WP_215625165.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| JFL75_RS02740 (JFL75_13025) | 546448..546708 | + | 261 | WP_215625166.1 | Txe/YoeB family addiction module toxin | - |
| JFL75_RS02745 (JFL75_13030) | 547015..547254 | + | 240 | WP_215625167.1 | ribbon-helix-helix domain-containing protein | - |
| JFL75_RS02750 (JFL75_13035) | 547251..547661 | + | 411 | WP_215625168.1 | putative toxin-antitoxin system toxin component, PIN family | - |
| JFL75_RS02755 (JFL75_13040) | 547692..548261 | - | 570 | WP_215625169.1 | TetR/AcrR family transcriptional regulator | - |
| JFL75_RS02760 (JFL75_13045) | 548393..549448 | + | 1056 | WP_215625170.1 | acyltransferase | - |
| JFL75_RS02765 (JFL75_13050) | 549586..549825 | + | 240 | WP_215625171.1 | DUF6364 family protein | - |
| JFL75_RS02770 (JFL75_13055) | 549818..550234 | + | 417 | WP_215625172.1 | PIN domain-containing protein | - |
| JFL75_RS02775 (JFL75_13060) | 550343..550831 | + | 489 | WP_215625173.1 | TspO/MBR family protein | - |
| JFL75_RS02780 (JFL75_13065) | 550954..551184 | + | 231 | WP_215625174.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| JFL75_RS02785 (JFL75_13070) | 551185..551580 | + | 396 | WP_215625175.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| JFL75_RS02790 (JFL75_13075) | 551894..552517 | + | 624 | WP_215625176.1 | DUF6266 family protein | - |
| JFL75_RS02795 (JFL75_13080) | 552550..552777 | - | 228 | WP_215625177.1 | hypothetical protein | - |
| JFL75_RS02800 (JFL75_13085) | 552924..553130 | + | 207 | WP_215625178.1 | helix-turn-helix transcriptional regulator | - |
| JFL75_RS02805 (JFL75_13090) | 553292..554488 | + | 1197 | WP_215625179.1 | three-Cys-motif partner protein TcmP | - |
| JFL75_RS02810 (JFL75_13095) | 554506..555264 | + | 759 | WP_215625180.1 | radical SAM protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 132 a.a. Molecular weight: 15153.53 Da Isoelectric Point: 5.7723
>T185709 WP_215625175.1 NZ_CP067089:551185-551580 [Breznakiella homolactica]
MYLLDTNICIYIINKRPQVVIEKIKTLEPIDIKLSSVSVSELEYGVSKSKFREKNREALIHFISGFDIIPFNEIDAEVYG
LIRADLENRGEIIGPYDMHIASQAISRNLILVTNNTNEFQRIKNLKLENWV
MYLLDTNICIYIINKRPQVVIEKIKTLEPIDIKLSSVSVSELEYGVSKSKFREKNREALIHFISGFDIIPFNEIDAEVYG
LIRADLENRGEIIGPYDMHIASQAISRNLILVTNNTNEFQRIKNLKLENWV
Download Length: 396 bp
>T185709 NZ_CP089001:358529-358876 [Klebsiella pneumoniae]
ATGTGGGATGTGGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATAAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA
ATGTGGGATGTGGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATAAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8807.04 Da Isoelectric Point: 9.9293
>AT185709 WP_215625174.1 NZ_CP067089:550954-551184 [Breznakiella homolactica]
MQSTKVFISGNSQAIRLPKEYQVDEKELYVQKIGGTIILLSKKNPWDAFEKSLDEFSDDFLSSGRKQPKRQKRESL
MQSTKVFISGNSQAIRLPKEYQVDEKELYVQKIGGTIILLSKKNPWDAFEKSLDEFSDDFLSSGRKQPKRQKRESL
Download Length: 231 bp
>AT185709 NZ_CP089001:358876-359175 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCCTAAAAAGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCCTAAAAAGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|