Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 331127..331752 Replicon chromosome
Accession NZ_CP067089
Organism Breznakiella homolactica strain RmG30

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JFL75_RS01680 Protein ID WP_215624967.1
Coordinates 331357..331752 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JFL75_RS01675 Protein ID WP_215624966.1
Coordinates 331127..331357 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFL75_RS01660 (JFL75_11945) 327314..327865 + 552 WP_215624963.1 hypothetical protein -
JFL75_RS01665 (JFL75_11950) 328382..329701 + 1320 WP_215624964.1 hypothetical protein -
JFL75_RS01670 (JFL75_11955) 329967..331019 + 1053 WP_215624965.1 hypothetical protein -
JFL75_RS01675 (JFL75_11960) 331127..331357 + 231 WP_215624966.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JFL75_RS01680 (JFL75_11965) 331357..331752 + 396 WP_215624967.1 type II toxin-antitoxin system VapC family toxin Toxin
JFL75_RS01685 (JFL75_11970) 332163..332525 - 363 WP_215624968.1 helix-turn-helix domain-containing protein -
JFL75_RS01690 (JFL75_11975) 332691..333200 + 510 WP_215624969.1 NAD(P)H-dependent oxidoreductase -
JFL75_RS01695 (JFL75_11980) 333912..334433 + 522 WP_215624970.1 hypothetical protein -
JFL75_RS01700 (JFL75_11985) 334441..334995 + 555 WP_215624971.1 hypothetical protein -
JFL75_RS01705 (JFL75_11990) 334992..335588 + 597 WP_215624972.1 hypothetical protein -
JFL75_RS01710 (JFL75_11995) 335711..336157 + 447 WP_215624973.1 MarR family transcriptional regulator -
JFL75_RS01715 (JFL75_12000) 336154..336732 + 579 WP_215624974.1 flavin reductase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 327314..335588 8274


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14921.61 Da        Isoelectric Point: 9.3362

>T185708 WP_215624967.1 NZ_CP067089:331357-331752 [Breznakiella homolactica]
MYLLDTNICIYIIKEQPEAVLKNLRKKRSKGMAISSITLAELEYGVENSKYPEKNKIALIKFLSIISILPFDAKAAEAYG
KIKADLKRRGCIIRPLDILIAAHAKSEDLILVTNNSKEFERVEDLKIENWV

Download         Length: 396 bp

>T185708 NZ_CP089001:332559-332927 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGACAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8790.73 Da        Isoelectric Point: 4.3063

>AT185708 WP_215624966.1 NZ_CP067089:331127-331357 [Breznakiella homolactica]
MQTAKLFTNGRSQAVRLPKDYQFNGEDVYIQKVGDAVILFPKDKDWEIFLDGLNSFSDDFLSEGRDQRTEGERETL

Download         Length: 231 bp

>AT185708 NZ_CP089001:332341-332562 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References