Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 256506..257131 Replicon chromosome
Accession NZ_CP067089
Organism Breznakiella homolactica strain RmG30

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JFL75_RS01240 Protein ID WP_215624883.1
Coordinates 256736..257131 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JFL75_RS01235 Protein ID WP_215624882.1
Coordinates 256506..256736 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFL75_RS01200 (JFL75_11490) 251618..252475 + 858 WP_215624875.1 hypothetical protein -
JFL75_RS01205 (JFL75_11495) 252501..252956 + 456 WP_223292740.1 effector binding domain-containing protein -
JFL75_RS01210 (JFL75_11500) 253077..253304 + 228 WP_215624877.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
JFL75_RS01215 (JFL75_11505) 253305..253694 + 390 WP_215624878.1 type II toxin-antitoxin system death-on-curing family toxin -
JFL75_RS01220 (JFL75_11510) 253824..254528 + 705 WP_215624879.1 JAB domain-containing protein -
JFL75_RS01225 (JFL75_11515) 254565..255176 + 612 WP_215624880.1 hypothetical protein -
JFL75_RS01230 (JFL75_11520) 255160..256158 + 999 WP_215624881.1 hypothetical protein -
JFL75_RS01235 (JFL75_11525) 256506..256736 + 231 WP_215624882.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JFL75_RS01240 (JFL75_11530) 256736..257131 + 396 WP_215624883.1 type II toxin-antitoxin system VapC family toxin Toxin
JFL75_RS01245 (JFL75_11535) 257711..260326 - 2616 WP_215624884.1 DEAD/DEAH box helicase family protein -
JFL75_RS01250 (JFL75_11540) 260344..262104 - 1761 WP_215624885.1 site-specific DNA-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14899.64 Da        Isoelectric Point: 10.0282

>T185707 WP_215624883.1 NZ_CP067089:256736-257131 [Breznakiella homolactica]
MYLLDTNICLYLIKERPEAVLKNLRKKRSKGIAISSITLAELEYGVENSKFPEKNKIALIKFLSIITILPFEAKAAEAYG
KIKADLKRRGRIIGPLDILIAAHAKSEDLVLVTNNTREFERIADVKIENWM

Download         Length: 396 bp

>T185707 NZ_CP089000:278218-278367 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8588.67 Da        Isoelectric Point: 4.2404

>AT185707 WP_215624882.1 NZ_CP067089:256506-256736 [Breznakiella homolactica]
MQTAKLFTNGRSQAVRLPKDYQFIGEDVYIQKVGDAVILFPKDKDWEIFLDGLNSFSDDFLADGCDQGIKGEREAL

Download         Length: 231 bp

>AT185707 NZ_CP089000:c278173-278114 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References