Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacT-ataR/DUF1778(antitoxin)
Location 355984..356750 Replicon plasmid pAtAB2-73d
Accession NZ_CP067074
Organism Rhizobium sp. AB2/73

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag I8E17_RS32700 Protein ID WP_209159800.1
Coordinates 355984..356466 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag I8E17_RS32705 Protein ID WP_209159801.1
Coordinates 356466..356750 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I8E17_RS32665 (I8E17_32480) 351379..352005 + 627 WP_209159793.1 thermonuclease family protein -
I8E17_RS32670 (I8E17_32485) 352002..352634 + 633 WP_209159794.1 thermonuclease family protein -
I8E17_RS32675 (I8E17_32490) 352635..352949 + 315 WP_209159795.1 hypothetical protein -
I8E17_RS32680 (I8E17_32495) 352958..353329 + 372 WP_209159796.1 hypothetical protein -
I8E17_RS32685 (I8E17_32500) 353360..353893 + 534 WP_229002329.1 hypothetical protein -
I8E17_RS32690 (I8E17_32505) 353928..354266 - 339 WP_209159798.1 helix-turn-helix domain-containing protein -
I8E17_RS32695 (I8E17_32510) 354576..355922 + 1347 WP_209159799.1 hypothetical protein -
I8E17_RS32700 (I8E17_32515) 355984..356466 - 483 WP_209159800.1 GNAT family N-acetyltransferase Toxin
I8E17_RS32705 (I8E17_32520) 356466..356750 - 285 WP_209159801.1 DUF1778 domain-containing protein Antitoxin
I8E17_RS32710 (I8E17_32525) 356992..357336 - 345 WP_209159802.1 hypothetical protein -
I8E17_RS32715 (I8E17_32530) 357431..360217 - 2787 WP_209159803.1 type IV secretory system conjugative DNA transfer family protein -
I8E17_RS32720 (I8E17_32535) 360186..361235 - 1050 WP_209159804.1 P-type DNA transfer ATPase VirB11 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..605540 605540


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-141)

Antitoxin

Vibrio phage ICP1, Orf50

(15-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17320.86 Da        Isoelectric Point: 7.2427

>T185703 WP_209159800.1 NZ_CP067074:c356466-355984 [Rhizobium sp. AB2/73]
MLSAPALLEEAHDLDLFQSGNDTLDEWLRRRARPNQVSGASRTYVVAEGQRVVGYYCLASGALDLADAPGSVRRNMPDPI
PMAVLGRLAIDRGWQGRGLGAALLQDAVLRTSQAASIMGIRGLLVHAISEDAKAFYEHYGFLCSPNQPMTLVLSLKIRTG

Download         Length: 483 bp

>T185703 NZ_CP088998:3002-3268 [Klebsiella pneumoniae]
TTGGTCTGGACGATTAACTATTCCGATCGGGCGCTCAAATCGTTACGCAAGATGGACAAACAGAACGCACGACGGATTGT
GGATTTTATGAGTTTACGCATTGCAGTTGCTGCCGATCCTCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGCTATCGGGTGGGAGATTATCGCGTTCTGTGTGAGATCCGAGATGACGAGCTTGTTATCCTTGCCGCCACGATT
GGACATCGCCGCGAAGTTTACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10723.12 Da        Isoelectric Point: 7.3189

>AT185703 WP_209159801.1 NZ_CP067074:c356750-356466 [Rhizobium sp. AB2/73]
MATKSLTDSHAKPVHLRIREDVRKVIDRAASIRGKSRTDFMIDAAYRAAEDALLDQTLVRVDEDSYRHFLSVLDQPPNGE
GFERLMNAPKPWQS

Download         Length: 285 bp

>AT185703 NZ_CP088998:2794-3018 [Klebsiella pneumoniae]
ATGCTTGCTATCCGGTTATCTGATGAGATTGAGTCCCGTCTGGACTCGCTGGCGAAGCAAACCGGCAGAACAAAGACGTT
TTATGCGCGGGAAGCAATACTGGCGCATCTGGAAGACCTGGAGGATTATTATCTTTCAGCAGAAACTGCTGCACGCGTTC
GCCGTGGTGATGAAGCAGTGCATTCGTCTGAAGACGTGAGGAAGTCACTTGGTCTGGACGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References