Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 958796..959349 Replicon plasmid pAtAB2-73e
Accession NZ_CP067073
Organism Rhizobium sp. AB2/73

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag I8E17_RS30490 Protein ID WP_069614884.1
Coordinates 958796..959089 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag I8E17_RS30495 Protein ID WP_113367594.1
Coordinates 959077..959349 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I8E17_RS30465 (I8E17_30330) 954430..955494 + 1065 WP_069614888.1 ABC transporter ATP-binding protein -
I8E17_RS30470 (I8E17_30335) 955491..956348 + 858 WP_113367595.1 ABC transporter permease -
I8E17_RS30475 (I8E17_30340) 956348..957130 + 783 WP_069614886.1 ABC transporter permease -
I8E17_RS30480 (I8E17_30345) 957320..958513 - 1194 WP_069614885.1 S53 family peptidase -
I8E17_RS30485 (I8E17_30350) 958513..958671 - 159 Protein_918 hypothetical protein -
I8E17_RS30490 (I8E17_30355) 958796..959089 - 294 WP_069614884.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I8E17_RS30495 (I8E17_30360) 959077..959349 - 273 WP_113367594.1 CopG family ribbon-helix-helix protein Antitoxin
I8E17_RS30500 (I8E17_30365) 959806..960390 - 585 WP_069614882.1 TetR/AcrR family transcriptional regulator -
I8E17_RS30505 (I8E17_30370) 960522..961397 + 876 WP_229002237.1 alpha/beta hydrolase -
I8E17_RS30510 (I8E17_30375) 961752..962279 - 528 WP_069614881.1 DUF4269 domain-containing protein -
I8E17_RS30515 (I8E17_30380) 962663..962881 + 219 WP_069614879.1 hypothetical protein -
I8E17_RS30520 (I8E17_30385) 963431..964267 + 837 WP_113367593.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..1068678 1068678


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-95)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10716.32 Da        Isoelectric Point: 8.0341

>T185702 WP_069614884.1 NZ_CP067073:c959089-958796 [Rhizobium sp. AB2/73]
VPRVIVTEGAAQGLERCRRFLAAKAPTAASRAGRAIERQFLLLESTPLIGRPLPDDAQLRELVIPFGDSGYVALYRHEPD
GDIVFVLAFRHQKEAGY

Download         Length: 294 bp

>T185702 NZ_CP088997:c5359999-5359616 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10570.65 Da        Isoelectric Point: 4.7301

>AT185702 WP_113367594.1 NZ_CP067073:c959349-959077 [Rhizobium sp. AB2/73]
MATSLKIDDELKNRVQNLASQRRRSAHWIILEAIQQYVEREEARENFKQEALASWAAYQETGRHLTGQEVRTWLDTWGTD
AEETVPECHE

Download         Length: 273 bp

>AT185702 NZ_CP088997:c5360241-5359999 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References