Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 807639..808315 Replicon plasmid pAtAB2-73f
Accession NZ_CP067072
Organism Rhizobium sp. AB2/73

Toxin (Protein)


Gene name vapC Uniprot ID A0A1E4Y2Q6
Locus tag I8E17_RS23350 Protein ID WP_069615564.1
Coordinates 807639..808061 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1E4Y2P7
Locus tag I8E17_RS23355 Protein ID WP_069615565.1
Coordinates 808058..808315 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I8E17_RS23330 (I8E17_23275) 803281..803862 + 582 WP_069615560.1 nucleoside 2-deoxyribosyltransferase -
I8E17_RS23335 (I8E17_23280) 803894..804670 - 777 WP_069615561.1 PhnD/SsuA/transferrin family substrate-binding protein -
I8E17_RS23340 (I8E17_23285) 804716..805720 - 1005 WP_069615562.1 ornithine cyclodeaminase family protein -
I8E17_RS23345 (I8E17_23290) 805831..807345 - 1515 WP_069615563.1 histidine ammonia-lyase -
I8E17_RS23350 (I8E17_23295) 807639..808061 - 423 WP_069615564.1 type II toxin-antitoxin system VapC family toxin Toxin
I8E17_RS23355 (I8E17_23300) 808058..808315 - 258 WP_069615565.1 plasmid stability protein stbC Antitoxin
I8E17_RS23360 (I8E17_23305) 808556..809302 - 747 WP_069615566.1 ATP-binding cassette domain-containing protein -
I8E17_RS23365 (I8E17_23310) 809295..810359 - 1065 WP_069615567.1 ribose ABC transporter -
I8E17_RS23370 (I8E17_23315) 810468..811457 - 990 WP_069615568.1 substrate-binding domain-containing protein -
I8E17_RS23375 (I8E17_23320) 811686..813098 - 1413 WP_069615702.1 ROK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - katA 1..1332287 1332287


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15359.75 Da        Isoelectric Point: 5.1409

>T185701 WP_069615564.1 NZ_CP067072:c808061-807639 [Rhizobium sp. AB2/73]
MIVLDTNVISELWKITPDPNVLSWIDAQMIETLYLSIITVAELRFGLAAMPEGKRRTIYQGRLEREVLPAFANRVLPFDL
DASQAYADLMALARRAGKSIGTADGYIAATAASHGFMVATRDTSPFEAGGLSVINPWNMK

Download         Length: 423 bp

>T185701 NZ_CP088997:c5036482-5035565 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9241.52 Da        Isoelectric Point: 7.2063

>AT185701 WP_069615565.1 NZ_CP067072:c808315-808058 [Rhizobium sp. AB2/73]
MASITIRNVSDEVHRAIRVRAAMHGRSTEAEIRDILEKAAKPEGRLKLGSLLTSIAREAGGLTEAEAEGFNQLRDKTPVG
PISFE

Download         Length: 258 bp

>AT185701 NZ_CP088997:c5037246-5036488 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGTCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E4Y2Q6

Antitoxin

Source ID Structure
AlphaFold DB A0A1E4Y2P7

References