Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 545705..546375 Replicon plasmid pAtAB2-73f
Accession NZ_CP067072
Organism Rhizobium sp. AB2/73

Toxin (Protein)


Gene name vapC Uniprot ID A0A1E4Y5D1
Locus tag I8E17_RS22210 Protein ID WP_069614530.1
Coordinates 545971..546375 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1E4Y5E1
Locus tag I8E17_RS22205 Protein ID WP_069614531.1
Coordinates 545705..545974 (+) Length 90 a.a.

Genomic Context

I8E17_RS22185I8E17_RS22195I8E17_RS22200I8E17_RS22205I8E17_RS22210I8E17_RS22225I8E17_RS22190I8E17_RS22215I8E17_RS22220
Location: 540746..541459 (714 bp)
Type: Others
Protein ID: WP_069614535.1
Location: 543133..544584 (1452 bp)
Type: Others
Protein ID: WP_069614533.1
Location: 544581..545540 (960 bp)
Type: Others
Protein ID: WP_069614532.1
Location: 545705..545974 (270 bp)
Type: Antitoxin
Protein ID: WP_069614531.1
Location: 545971..546375 (405 bp)
Type: Toxin
Protein ID: WP_069614530.1
Location: 548199..549611 (1413 bp)
Type: Others
Protein ID: WP_069614527.1
Location: 541431..542858 (1428 bp)
Type: Others
Protein ID: WP_069614534.1
Location: 546432..546677 (246 bp)
Type: Others
Protein ID: WP_069614529.1
Location: 546704..547993 (1290 bp)
Type: Others
Protein ID: WP_069614528.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
I8E17_RS22185 (I8E17_22145)540746..541459+714WP_069614535.1FadR/GntR family transcriptional regulator-
I8E17_RS22190 (I8E17_22150)541431..542858-1428WP_069614534.1aspartate ammonia-lyase-
I8E17_RS22195 (I8E17_22155)543133..544584+1452WP_069614533.1amino acid permease-
I8E17_RS22200 (I8E17_22160)544581..545540+960WP_069614532.1asparaginase-
I8E17_RS22205 (I8E17_22165)545705..545974+270WP_069614531.1antitoxinAntitoxin
I8E17_RS22210 (I8E17_22170)545971..546375+405WP_069614530.1type II toxin-antitoxin system VapC family toxinToxin
I8E17_RS22215 (I8E17_22175)546432..546677-246WP_069614529.1hypothetical protein-
I8E17_RS22220 (I8E17_22180)546704..547993-1290WP_069614528.1isocitrate lyase-
I8E17_RS22225 (I8E17_22185)548199..549611+1413WP_069614527.1XRE family transcriptional regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid-katA1..13322871332287


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(18-56)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14308.68 Da        Isoelectric Point: 5.1871

>T185700 WP_069614530.1 NZ_CP067072:545971-546375 [Rhizobium sp. AB2/73]
MSKLYMLDTNIVSELARNPQGIVARRIADVGPDAICVSIITAAELRYGCAKKGSPKLLAQIEAILGSIPVLALDVPADAE
YGAIRAELEVAGKPIGPNDLLIAAHAHALEAVLVTANIGEFKRVRDLRVENWLD

Download         Length: 405 bp

>T185700 NZ_CP088997:c4879665-4879381 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10269.78 Da        Isoelectric Point: 5.6560

>AT185700 WP_069614531.1 NZ_CP067072:545705-545974 [Rhizobium sp. AB2/73]
MRHLRHNEPSPPREAKLFRNNKSQAVRIPADFELPGDRVMIHREGDRLIIEPVRRKSLLDVLASLEPLGPEDQFPDIDDT
LLPAKEIEL

Download         Length: 270 bp

>AT185700 NZ_CP088997:c4879897-4879655 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1E4Y5D1

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1E4Y5E1

References