Detailed information of TA system TA185699

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3991092..3991735
• Replicon: chromosome
• Accession: NZ_CP067071
• Organism: Rhizobium sp. AB2/73

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: I8E17_RS19630
• Protein ID: WP_113366582.1
• Coordinates: 3991092..3991496 (-)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: I8E17_RS19635
• Protein ID: WP_113366583.1
• Coordinates: 3991493..3991735 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I8E17_RS19595 (I8E17_19580)	3986171..3987082	+	912	WP_113366577.1	LysR family transcriptional regulator	-
I8E17_RS19600 (I8E17_19585)	3987128..3988003	-	876	WP_069611108.1	LysR family transcriptional regulator	-
I8E17_RS19605 (I8E17_19590)	3988102..3989385	+	1284	WP_113366578.1	MFS transporter	-
I8E17_RS19610 (I8E17_19595)	3989400..3989786	+	387	WP_069611110.1	VOC family protein	-
I8E17_RS19615 (I8E17_19600)	3989878..3990219	+	342	WP_113366579.1	metalloregulator ArsR/SmtB family transcription factor	-
I8E17_RS19620 (I8E17_19605)	3990203..3990685	+	483	WP_113366580.1	SRPBCC domain-containing protein	-
I8E17_RS19625 (I8E17_19610)	3990691..3991095	+	405	WP_113366581.1	GFA family protein	-
I8E17_RS19630 (I8E17_19615)	3991092..3991496	-	405	WP_113366582.1	type II toxin-antitoxin system VapC family toxin	Toxin
I8E17_RS19635 (I8E17_19620)	3991493..3991735	-	243	WP_113366583.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
I8E17_RS19640 (I8E17_19625)	3991801..3992475	-	675	WP_113366584.1	hypothetical protein	-
I8E17_RS19645 (I8E17_19630)	3992545..3994206	-	1662	WP_113366585.1	urocanate hydratase	-
I8E17_RS19650 (I8E17_19635)	3994249..3994578	-	330	WP_069611116.1	TfoX/Sxy family protein	-
I8E17_RS19655 (I8E17_19640)	3994597..3995697	-	1101	WP_069611117.1	DUF917 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-122)

Antitoxin

• SpoVT-AbrB domain (7-43)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 14753.00 Da
• Isoelectric Point: 8.4869

>T185699 WP_113366582.1 NZ_CP067071:c3991496-3991092 [Rhizobium sp. AB2/73]
VKYLLDSNAIIALMKGHPGFVGKLRRHKPQDFAIPAIVAHELIYGAYKGQRVSDNLARVDALQFETLDFDKQDARVAGEI
RASLASLGTPIGAYDVLIAGQAVARDLILITHNVKEFGRVPKLRFEDWESLPSG

Nucleotide

• Length: 405 bp

>T185699 NZ_CP088997:c4776623-4776090 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9285.42 Da
• Isoelectric Point: 4.2296

>AT185699 WP_113366583.1 NZ_CP067071:c3991735-3991493 [Rhizobium sp. AB2/73]
MDTAKIFWSGRSQAVRLPKEFRLDGEEVRIRRQGKAIILEPITEDWDWLEAVTGPVDDDFVEAATEQPAEQQRPELDIFK

Nucleotide

• Length: 243 bp

>AT185699 NZ_CP088997:c4776900-4776634 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA