Detailed information of TA system TA185698

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-parD/RelE-RHH
• Location: 3694045..3694628
• Replicon: chromosome
• Accession: NZ_CP067071
• Organism: Rhizobium sp. AB2/73

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: I8E17_RS18105
• Protein ID: WP_113366807.1
• Coordinates: 3694045..3694341 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: I8E17_RS18110
• Protein ID: WP_113366806.1
• Coordinates: 3694338..3694628 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I8E17_RS18075 (I8E17_18065)	3689305..3690081	-	777	WP_113366811.1	phosphonate C-P lyase system protein PhnK	-
I8E17_RS18080 (I8E17_18070)	3690078..3690989	-	912	WP_069610920.1	alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase PhnJ	-
I8E17_RS18085 (I8E17_18075)	3690986..3692095	-	1110	WP_113366810.1	carbon-phosphorus lyase complex subunit PhnI	-
I8E17_RS18090 (I8E17_18080)	3692099..3692725	-	627	WP_113366809.1	phosphonate C-P lyase system protein PhnH	-
I8E17_RS18095 (I8E17_18085)	3692725..3693201	-	477	WP_112722845.1	phosphonate C-P lyase system protein PhnG	-
I8E17_RS18100 (I8E17_18090)	3693303..3694037	+	735	WP_113366808.1	phosphonate metabolism transcriptional regulator PhnF	-
I8E17_RS18105 (I8E17_18095)	3694045..3694341	-	297	WP_113366807.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I8E17_RS18110 (I8E17_18100)	3694338..3694628	-	291	WP_113366806.1	hypothetical protein	Antitoxin
I8E17_RS18115 (I8E17_18105)	3694728..3695363	-	636	WP_112722848.1	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase	-
I8E17_RS18120 (I8E17_18110)	3695485..3696309	-	825	WP_113366805.1	4-hydroxy-tetrahydrodipicolinate reductase	-
I8E17_RS18125 (I8E17_18115)	3696324..3698117	-	1794	WP_112722850.1	ABC transporter ATP-binding protein	-
I8E17_RS18130 (I8E17_18120)	3698329..3699351	-	1023	WP_112722851.1	glucokinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-89)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11175.92 Da
• Isoelectric Point: 9.5301

>T185698 WP_113366807.1 NZ_CP067071:c3694341-3694045 [Rhizobium sp. AB2/73]
VKLAWTPEARADRRAIYTYIEAENATAALALDELLAKRSKQLITHPMTGRPGRVSGTRELVVHRNYLLVYDLADEMVRII
RILHAAQQWPPSDFQPIP

Nucleotide

• Length: 297 bp

>T185698 NZ_CP088997:4163801-4164019 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10872.98 Da
• Isoelectric Point: 4.6812

>AT185698 WP_113366806.1 NZ_CP067071:c3694628-3694338 [Rhizobium sp. AB2/73]
MTDATFTFRVEEELKAAFSEAAKAHDQTGAQLLRAFMRDYVRRQQDAAEYDIWFRQQVQAGLTSANAGNLIPDDDVDAEF
AALREETRRKLSGRSS

Nucleotide

• Length: 291 bp

>AT185698 NZ_CP088997:4163400-4163774 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG