Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 2423670..2424334 Replicon chromosome
Accession NZ_CP067071
Organism Rhizobium sp. AB2/73

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag I8E17_RS12050 Protein ID WP_113366625.1
Coordinates 2423924..2424334 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapC Uniprot ID A0A1E4YDV8
Locus tag I8E17_RS12045 Protein ID WP_069611741.1
Coordinates 2423670..2423924 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I8E17_RS12015 (I8E17_12005) 2419310..2419816 - 507 WP_069611735.1 VOC family protein -
I8E17_RS12020 (I8E17_12010) 2419816..2420205 - 390 WP_069611736.1 RidA family protein -
I8E17_RS12025 (I8E17_12015) 2420267..2421163 - 897 WP_069611737.1 DMT family transporter -
I8E17_RS12030 (I8E17_12020) 2421411..2421836 + 426 WP_069611738.1 hypothetical protein -
I8E17_RS12035 (I8E17_12025) 2421887..2422498 - 612 WP_069611739.1 alpha/beta hydrolase -
I8E17_RS12040 (I8E17_12030) 2422514..2423446 - 933 WP_069611740.1 VOC family protein -
I8E17_RS12045 (I8E17_12035) 2423670..2423924 + 255 WP_069611741.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
I8E17_RS12050 (I8E17_12040) 2423924..2424334 + 411 WP_113366625.1 type II toxin-antitoxin system VapC family toxin Toxin
I8E17_RS12055 (I8E17_12045) 2424328..2425029 - 702 WP_069611743.1 uracil-DNA glycosylase -
I8E17_RS12060 (I8E17_12050) 2425258..2425797 + 540 WP_069611744.1 AAA family ATPase -
I8E17_RS12065 (I8E17_12055) 2425810..2428257 - 2448 WP_069611745.1 FAD-dependent oxidoreductase -
I8E17_RS12070 (I8E17_12060) 2428267..2429145 - 879 WP_069611746.1 choline/ethanolamine kinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-69)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15390.63 Da        Isoelectric Point: 8.5732

>T185697 WP_113366625.1 NZ_CP067071:2423924-2424334 [Rhizobium sp. AB2/73]
MYLVDTNVVSELRRGNSQAIAWLRSVDPSTIYLSVITLGEIMRGIALKRKSDPRTATHLEEWLRKLRHDHRNRILPITDQ
IAVEWGRIAAQRPRGDADGLIAATAIVHDLIVVTRNIGDFDDTGALIVNPWDQKPY

Download         Length: 411 bp

>T185697 NZ_CP088997:c3250931-3250829 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9138.28 Da        Isoelectric Point: 4.3951

>AT185697 WP_069611741.1 NZ_CP067071:2423670-2423924 [Rhizobium sp. AB2/73]
MNWPLQDAKNQFSKVVQKARSEGPQIVTLRGEPAAVVLSAEDYDALLAGKPSLADDLLSGPAWDDEIAEAVSKRDKTPSR
DVLF

Download         Length: 255 bp

>AT185697 NZ_CP088997:3250822-3250967 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1E4YDV8

References