Detailed information of TA system TA185692

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 551464..551944
• Replicon: chromosome
• Accession: NZ_CP067071
• Organism: Rhizobium sp. AB2/73

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: I8E17_RS02805
• Protein ID: WP_083258227.1
• Coordinates: 551672..551944 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A0A1E4Y816
• Locus tag: I8E17_RS02800
• Protein ID: WP_069613789.1
• Coordinates: 551464..551688 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I8E17_RS02765 (I8E17_02760)	546601..546930	+	330	WP_069613782.1	NIPSNAP family protein	-
I8E17_RS02770 (I8E17_02765)	546927..547274	+	348	WP_069613783.1	antibiotic biosynthesis monooxygenase	-
I8E17_RS02775 (I8E17_02770)	547431..548561	+	1131	WP_069613784.1	site-specific DNA-methyltransferase	-
I8E17_RS02780 (I8E17_02775)	548693..549058	-	366	WP_069613785.1	nuclear transport factor 2 family protein	-
I8E17_RS02785 (I8E17_02780)	549063..549677	-	615	WP_069613786.1	HAD family phosphatase	-
I8E17_RS02790 (I8E17_02785)	549674..550789	-	1116	WP_176728026.1	A/G-specific adenine glycosylase	-
I8E17_RS02795 (I8E17_02790)	550885..551379	+	495	WP_069613788.1	DUF721 domain-containing protein	-
I8E17_RS02800 (I8E17_02795)	551464..551688	+	225	WP_069613789.1	DUF6290 family protein	Antitoxin
I8E17_RS02805 (I8E17_02800)	551672..551944	+	273	WP_083258227.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I8E17_RS02810 (I8E17_02805)	552126..552815	+	690	WP_069613791.1	DsbA family protein	-
I8E17_RS02815 (I8E17_02810)	553002..556463	+	3462	WP_069613792.1	chromosome segregation SMC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-88)

Antitoxin

• Relaxosome protein TraY (4-49)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10684.37 Da
• Isoelectric Point: 10.3041

>T185692 WP_083258227.1 NZ_CP067071:551672-551944 [Rhizobium sp. AB2/73]
MAWRIEFQRAAERELDKLGHEVSRRILKFLYDRVAKLDDPRAIGEALKGSELGDFWKYRVGDYRIIAHIEDRAVRILIVR
IGNGREVYRK

Nucleotide

• Length: 273 bp

>T185692 NZ_CP088997:328118-328486 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8519.69 Da
• Isoelectric Point: 4.5593

>AT185692 WP_069613789.1 NZ_CP067071:551464-551688 [Rhizobium sp. AB2/73]
MLALRLPPEIEARLDELAKRTGRSKSFYAREAILEHLDDLEDIYLAEKRLEELRRGESDTVSLAELMARYGVAD

Nucleotide

• Length: 225 bp

>AT185692 NZ_CP088997:327900-328121 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A1E4Y816