Detailed information of TA system TA185691

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 380986..381466
• Replicon: chromosome
• Accession: NZ_CP067071
• Organism: Rhizobium sp. AB2/73

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: I8E17_RS01940
• Protein ID: WP_083258161.1
• Coordinates: 380986..381255 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A0A1E4YCA6
• Locus tag: I8E17_RS01945
• Protein ID: WP_069612387.1
• Coordinates: 381239..381466 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I8E17_RS01915 (I8E17_01915)	376910..377959	+	1050	WP_069612382.1	aldo/keto reductase	-
I8E17_RS01920 (I8E17_01920)	378008..379033	-	1026	WP_069612383.1	NAD(P)-dependent alcohol dehydrogenase	-
I8E17_RS01925 (I8E17_01925)	379144..380043	+	900	WP_069612384.1	LysR family transcriptional regulator	-
I8E17_RS01930 (I8E17_01930)	380091..380459	-	369	WP_069612385.1	DUF305 domain-containing protein	-
I8E17_RS01935 (I8E17_01935)	380533..380910	-	378	WP_069612386.1	hypothetical protein	-
I8E17_RS01940 (I8E17_01940)	380986..381255	-	270	WP_083258161.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I8E17_RS01945 (I8E17_01945)	381239..381466	-	228	WP_069612387.1	DUF6290 family protein	Antitoxin
I8E17_RS01950 (I8E17_01950)	381640..383163	+	1524	WP_069612388.1	histidine--tRNA ligase	-
I8E17_RS01955 (I8E17_01955)	383224..384342	+	1119	WP_069612389.1	ATP phosphoribosyltransferase regulatory subunit	-
I8E17_RS01960 (I8E17_01960)	384342..385037	+	696	WP_069612390.1	ATP phosphoribosyltransferase	-
I8E17_RS01965 (I8E17_01965)	385114..385563	-	450	WP_069612391.1	DoxX family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-88)

Antitoxin

• Relaxosome protein TraY (7-50)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10621.19 Da
• Isoelectric Point: 10.3321

>T185691 WP_083258161.1 NZ_CP067071:c381255-380986 [Rhizobium sp. AB2/73]
VAWTIEYARSARKFVEKLNPETRKRIRSFLEERLATLHDPRQVGDALQGARLGNYWRYRVGDYRIICDLQDSRLVVLVIE
IGNRRDVYR

Nucleotide

• Length: 270 bp

>T185691 NZ_CP088996:c144346-143903 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8771.74 Da
• Isoelectric Point: 4.3135

>AT185691 WP_069612387.1 NZ_CP067071:c381466-381239 [Rhizobium sp. AB2/73]
MSKQTAIRLPDETYERLQALATRTGRTATFYIRQAVEAHLDEMEDVYLAERAMERIKNGEDEVVSSEEFWRGMDD

Nucleotide

• Length: 228 bp

>AT185691 NZ_CP088996:c144573-144343 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Structures

Antitoxin

• AlphaFold DB: A0A1E4YCA6