Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 59554..60290 Replicon plasmid unnamed2
Accession NZ_CP067068
Organism Raoultella sp. XY-1

Toxin (Protein)


Gene name tacT Uniprot ID A0A2J5Q928
Locus tag JGY86_RS27890 Protein ID WP_004098919.1
Coordinates 59554..60036 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A2J5Q9C0
Locus tag JGY86_RS27895 Protein ID WP_004098921.1
Coordinates 60024..60290 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGY86_RS27870 55920..56117 + 198 WP_035896695.1 hypothetical protein -
JGY86_RS27875 56355..57104 + 750 WP_098140154.1 phosphate-starvation-inducible PsiE family protein -
JGY86_RS27880 57091..58053 + 963 WP_098140155.1 M48 family metalloprotease -
JGY86_RS27885 58194..59395 + 1202 Protein_57 IS3 family transposase -
JGY86_RS27890 59554..60036 - 483 WP_004098919.1 GNAT family N-acetyltransferase Toxin
JGY86_RS27895 60024..60290 - 267 WP_004098921.1 DUF1778 domain-containing protein Antitoxin
JGY86_RS27900 60466..60720 - 255 WP_049078423.1 hypothetical protein -
JGY86_RS27905 60796..61053 - 258 WP_004098928.1 hypothetical protein -
JGY86_RS27910 61102..61305 - 204 WP_004098931.1 hemolysin expression modulator Hha -
JGY86_RS27915 61339..61707 - 369 WP_009653915.1 hypothetical protein -
JGY86_RS27920 61751..62245 - 495 WP_004118696.1 hypothetical protein -
JGY86_RS27925 62276..62843 - 568 Protein_65 hypothetical protein -
JGY86_RS27930 62840..63103 - 264 WP_004118691.1 hypothetical protein -
JGY86_RS27935 63417..63677 + 261 WP_017146633.1 type II toxin-antitoxin system ParD family antitoxin -
JGY86_RS27940 63664..63960 + 297 WP_017146632.1 type II toxin-antitoxin system RelE/ParE family toxin -
JGY86_RS27945 64140..64574 - 435 WP_017146631.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..135126 135126


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(66-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17335.06 Da        Isoelectric Point: 10.0704

>T185688 WP_004098919.1 NZ_CP067068:c60036-59554 [Raoultella sp. XY-1]
VGRITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKKVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

>T185688 NZ_CP088995:139558-139707 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGTGCCACGGTATTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10105.49 Da        Isoelectric Point: 4.5141

>AT185688 WP_004098921.1 NZ_CP067068:c60290-60024 [Raoultella sp. XY-1]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEIACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDDSAINKLL
ARKPQWDV

Download         Length: 267 bp

>AT185688 NZ_CP088995:c139513-139454 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J5Q928

Antitoxin

Source ID Structure
AlphaFold DB A0A2J5Q9C0

References