Detailed information of TA system TA185686

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): shpAB/BrnT-BrnA
• Location: 4799415..4799994
• Replicon: chromosome
• Accession: NZ_CP067066
• Organism: Raoultella sp. XY-1

Toxin (Protein)

• Gene name: shpA
• Uniprot ID: -
• Locus tag: JGY86_RS22600
• Protein ID: WP_088402415.1
• Coordinates: 4799707..4799994 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: -
• Locus tag: JGY86_RS22595
• Protein ID: WP_088402414.1
• Coordinates: 4799415..4799720 (-)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JGY86_RS22570	4794622..4795686	-	1065	WP_004857527.1	DUF2955 domain-containing protein	-
JGY86_RS22575	4795676..4796743	-	1068	WP_088402413.1	HlyD family secretion protein	-
JGY86_RS22580	4796750..4797214	-	465	WP_004857523.1	MarR family transcriptional regulator	-
JGY86_RS22585	4797505..4797669	-	165	WP_004857521.1	DUF1127 domain-containing protein	-
JGY86_RS22590	4797847..4799259	+	1413	WP_015585221.1	PLP-dependent aminotransferase family protein	-
JGY86_RS22595	4799415..4799720	-	306	WP_088402414.1	BrnA antitoxin family protein	Antitoxin
JGY86_RS22600	4799707..4799994	-	288	WP_088402415.1	BrnT family toxin	Toxin
JGY86_RS22605	4800111..4800530	-	420	WP_004857515.1	FosA family fosfomycin resistance glutathione transferase	-
JGY86_RS22610	4800524..4801432	-	909	WP_015585225.1	LysR family transcriptional regulator	-
JGY86_RS22615	4801520..4802302	+	783	WP_088402416.1	NAD(P)H-dependent oxidoreductase	-
JGY86_RS22620	4802450..4803028	+	579	WP_004857495.1	TetR/AcrR family transcriptional regulator	-
JGY86_RS22625	4803172..4803984	+	813	WP_088402417.1	winged helix-turn-helix domain-containing protein	-
JGY86_RS22630	4803981..4804499	+	519	WP_015585229.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (7-88)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (41-93)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11090.48 Da
• Isoelectric Point: 7.0744

>T185686 WP_088402415.1 NZ_CP067066:c4799994-4799707 [Raoultella sp. XY-1]
MPMEFEWDANKAASNLRKHGIRFEEAVLVFDDPQHLSRHDRYENGEYRWQTIGLVHGVIVVLVAHSIRFESGTEVIRIIS
ARKADGKERSRYEHS

Nucleotide

• Length: 288 bp

>T185686 NZ_CP088993:c8694-8380 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGCGATTTACAACGCCTTCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGGAGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CGTTTCTGCCGCTGGAATATAAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCAGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11705.13 Da
• Isoelectric Point: 8.3877

>AT185686 WP_088402414.1 NZ_CP067066:c4799720-4799415 [Raoultella sp. XY-1]
MSTVKYKRDNPAGLSAQREDELRALEKKSDDDIDYSDIPSSDDEPWSEAVRGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMIREQNKKS

Nucleotide

• Length: 306 bp

>AT185686 NZ_CP088993:c8960-8682 [Klebsiella pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AGGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCGGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA