Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4201010..4201629 Replicon chromosome
Accession NZ_CP067066
Organism Raoultella sp. XY-1

Toxin (Protein)


Gene name Hha Uniprot ID A0A514EV16
Locus tag JGY86_RS19750 Protein ID WP_004858783.1
Coordinates 4201411..4201629 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A514EV88
Locus tag JGY86_RS19745 Protein ID WP_004858785.1
Coordinates 4201010..4201384 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGY86_RS19735 4196121..4197314 + 1194 WP_004858789.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JGY86_RS19740 4197337..4200483 + 3147 WP_004858787.1 multidrug efflux RND transporter permease subunit -
JGY86_RS19745 4201010..4201384 + 375 WP_004858785.1 Hha toxicity modulator TomB Antitoxin
JGY86_RS19750 4201411..4201629 + 219 WP_004858783.1 hemolysin expression modulator Hha Toxin
JGY86_RS19755 4201781..4202347 + 567 WP_004858781.1 maltose O-acetyltransferase -
JGY86_RS19760 4202447..4202917 + 471 WP_004858780.1 YlaC family protein -
JGY86_RS19765 4202892..4204343 - 1452 WP_064357430.1 PLP-dependent aminotransferase family protein -
JGY86_RS19770 4204450..4205160 + 711 WP_015585015.1 GNAT family N-acetyltransferase -
JGY86_RS19775 4205157..4205297 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
JGY86_RS19780 4205300..4205560 - 261 WP_004858777.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8570.90 Da        Isoelectric Point: 7.9907

>T185685 WP_004858783.1 NZ_CP067066:4201411-4201629 [Raoultella sp. XY-1]
MSGEPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T185685 NZ_CP088992:c4448-4182 [Klebsiella pneumoniae]
TTGGTCTGGACGATTAACTATTCCGATCGGGCGCTCAAATCGTTACGCAAGATGGACAAACAGAACGCACGACGGATTGT
GGATTTTATGAGTTTACGCATTGCAGTTGCTGCCGATCCTCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGCTATCGGGTGGGAGATTATCGCGTTCTGTGTGAGATCCGAGATGACGAGCTTGTTATCCTTGCCGCCACGATT
GGACATCGCCGCGAAGTTTACGACTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14411.19 Da        Isoelectric Point: 4.8989

>AT185685 WP_004858785.1 NZ_CP067066:4201010-4201384 [Raoultella sp. XY-1]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYAEDNKLIAQLDEYL
DDTFMLFSSYGINTADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT185685 NZ_CP088992:c4656-4432 [Klebsiella pneumoniae]
ATGCTTGCTATCCGGTTATCTGATGAGATTGAGTCCCGTCTGGACTCGCTGGCGAAGCAAACCGGCAGAACAAAGACGTT
TTATGCGCGGGAAGCAATACTGGCGCATCTGGAAGACCTGGAGGATTATTATCTTTCAGCAGAAACTGCTGCACGCGTTC
GCCGTGGTGATGAAGCAGTGCATTCGTCTGAAGACGTGAGGAAGTCACTTGGTCTGGACGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A514EV16

Antitoxin

Source ID Structure
AlphaFold DB A0A514EV88

References