Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 2480518..2481431 Replicon chromosome
Accession NZ_CP067066
Organism Raoultella sp. XY-1

Toxin (Protein)


Gene name - Uniprot ID A0A808Y4A8
Locus tag JGY86_RS11705 Protein ID WP_015584188.1
Coordinates 2480518..2480991 (-) Length 158 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag JGY86_RS11710 Protein ID WP_032716402.1
Coordinates 2480988..2481431 (-) Length 148 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGY86_RS11680 2476560..2477168 - 609 WP_069475887.1 glutathione S-transferase family protein -
JGY86_RS11685 2477410..2478315 + 906 WP_100663613.1 LysR family transcriptional regulator -
JGY86_RS11690 2478343..2479248 - 906 WP_032716407.1 LysR family transcriptional regulator -
JGY86_RS11695 2479351..2479668 + 318 WP_004862785.1 nuclear transport factor 2 family protein -
JGY86_RS11700 2479661..2480440 + 780 WP_032716405.1 SDR family oxidoreductase -
JGY86_RS11705 2480518..2480991 - 474 WP_015584188.1 RES domain-containing protein Toxin
JGY86_RS11710 2480988..2481431 - 444 WP_032716402.1 DUF2384 domain-containing protein Antitoxin
JGY86_RS11715 2481621..2482187 - 567 WP_015584190.1 DJ-1/PfpI family protein -
JGY86_RS11720 2482585..2483367 + 783 WP_032717546.1 DUF3750 domain-containing protein -
JGY86_RS11725 2483564..2484787 + 1224 WP_200382711.1 zinc metallochaperone GTPase ZigA -
JGY86_RS11745 2485717..2486193 - 477 WP_072003719.1 acid resistance repetitive basic protein Asr -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-148)

Antitoxin

(95-144)


Sequences


Toxin        


Download         Length: 158 a.a.        Molecular weight: 17524.82 Da        Isoelectric Point: 4.8081

>T185682 WP_015584188.1 NZ_CP067066:c2480991-2480518 [Raoultella sp. XY-1]
MIFYRLVTGRYASEAWTGSGANQYGGRWNHQGHPAVYVSTSIALASLEILVHVKNEAILNQYQLYSIEIPDSEVESLDKQ
WLPDNWQENPMPVSTMDLGTGWLQSGSGLALMLPSCIIPYENNAILNPLHPAFSEALASVRQYPFTFDPRLARSTPL

Download         Length: 474 bp

>T185682 NZ_CP088991:c4915745-4915461 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16176.42 Da        Isoelectric Point: 4.9405

>AT185682 WP_032716402.1 NZ_CP067066:c2481431-2480988 [Raoultella sp. XY-1]
MKTWVPAEQPADNALWRYAGLPANRGMQLIELLSMGLPVSVLDNIHEWTEMSKTDILRITGINERNVARRKSAGGTLTPG
ESERVARFVRVLDTAVDYFGSKQDAYDWLQSPVRGLGNVAPIDLIATESGALEVTDLIGRLEHGVFA

Download         Length: 444 bp

>AT185682 NZ_CP088991:c4915977-4915735 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A808Y4A8


Antitoxin

Source ID Structure

References