Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 855754..856411 Replicon chromosome
Accession NZ_CP067066
Organism Raoultella sp. XY-1

Toxin (Protein)


Gene name cptA Uniprot ID A0A808XTM6
Locus tag JGY86_RS04145 Protein ID WP_004867355.1
Coordinates 856001..856411 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A514ELX1
Locus tag JGY86_RS04140 Protein ID WP_004867358.1
Coordinates 855754..856020 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGY86_RS04115 850889..852322 - 1434 WP_004867372.1 6-phospho-beta-glucosidase -
JGY86_RS04120 852442..853170 - 729 WP_004867368.1 MurR/RpiR family transcriptional regulator -
JGY86_RS04125 853220..853531 + 312 WP_004867365.1 N(4)-acetylcytidine aminohydrolase -
JGY86_RS04130 853693..854352 + 660 WP_004867362.1 hemolysin III family protein -
JGY86_RS04135 854474..855457 - 984 WP_088402302.1 tRNA-modifying protein YgfZ -
JGY86_RS04140 855754..856020 + 267 WP_004867358.1 FAD assembly factor SdhE Antitoxin
JGY86_RS04145 856001..856411 + 411 WP_004867355.1 protein YgfX Toxin
JGY86_RS04150 856419..856940 - 522 WP_004867353.1 flavodoxin FldB -
JGY86_RS04155 857119..858015 + 897 WP_015585784.1 site-specific tyrosine recombinase XerD -
JGY86_RS04160 858038..858751 + 714 WP_004867349.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JGY86_RS04165 858757..860490 + 1734 WP_088402300.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16226.16 Da        Isoelectric Point: 11.3349

>T185672 WP_004867355.1 NZ_CP067066:856001-856411 [Raoultella sp. XY-1]
VVLWQSDLRISWRSQWFSLLLHGIVAAIVLLMPWPLSYTPLWLLLLSLVVFDSVRSQRRIHACRGEIKLMTDSRLRWQKA
EWEIVGTPWVINSGMLLRLQDMQTRRRQHLWIAADSMDAKEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T185672 NZ_CP088990:112478-112960 [Klebsiella pneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCACTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGAAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCTACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGTGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGCGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10553.05 Da        Isoelectric Point: 4.8432

>AT185672 WP_004867358.1 NZ_CP067066:855754-856020 [Raoultella sp. XY-1]
MDITNKARIHWACRRGMRELDISIMPFFEYEYDTLSDEDKQLFIRLLENDDPDLFNWLMNHGEPADAQLQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT185672 NZ_CP088990:112224-112490 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGTACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGATTCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808XTM6

Antitoxin

Source ID Structure
AlphaFold DB A0A514ELX1

References