Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 67167..67714 Replicon chromosome
Accession NZ_CP067066
Organism Raoultella sp. XY-1

Toxin (Protein)


Gene name ccdB Uniprot ID A0A808XUV0
Locus tag JGY86_RS00315 Protein ID WP_048025274.1
Coordinates 67167..67475 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A808XYT1
Locus tag JGY86_RS00320 Protein ID WP_004869059.1
Coordinates 67478..67714 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGY86_RS00285 62346..62648 - 303 WP_004869065.1 PTS lactose/cellobiose transporter subunit IIA -
JGY86_RS00290 62783..64108 - 1326 WP_004869064.1 PTS cellobiose transporter subunit IIC -
JGY86_RS00295 64120..64434 - 315 WP_088402361.1 PTS sugar transporter subunit IIB -
JGY86_RS00300 64729..65670 + 942 WP_088402360.1 LacI family transcriptional regulator -
JGY86_RS00305 65765..66040 - 276 WP_160873538.1 hypothetical protein -
JGY86_RS00310 66149..67051 - 903 WP_015585496.1 EamA family transporter -
JGY86_RS00315 67167..67475 - 309 WP_048025274.1 CcdB family protein Toxin
JGY86_RS00320 67478..67714 - 237 WP_004869059.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
JGY86_RS00325 67820..69253 - 1434 WP_004869058.1 PTS N-acetylmuramic acid transporter subunit IIBC -
JGY86_RS00330 69278..70180 - 903 WP_088402359.1 N-acetylmuramic acid 6-phosphate etherase -
JGY86_RS00335 70345..71508 - 1164 WP_004869055.1 multidrug effflux MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11778.62 Da        Isoelectric Point: 6.7156

>T185671 WP_048025274.1 NZ_CP067066:c67475-67167 [Raoultella sp. XY-1]
IQYYVYKNTGRITVYPYLLDVQSDIIGMRNTRVVIPLFPLRNYKGPRADRLTPVVTVEGEEYVVMTHELASIPQRVLGEE
VCHLNHQREVVKASIDFLFDGI

Download         Length: 309 bp

>T185671 NZ_CP088990:44051-44521 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
TTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8898.08 Da        Isoelectric Point: 5.6579

>AT185671 WP_004869059.1 NZ_CP067066:c67714-67478 [Raoultella sp. XY-1]
MPAVKHNKQNVSVTLDPILVKQAREIGINLSQTLTSALKSEIHSIEMARWQKENARAIDYLNDLTEENGLLSDEYRTF

Download         Length: 237 bp

>AT185671 NZ_CP088990:43611-44054 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAATCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACGTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808XUV0

Antitoxin

Source ID Structure
AlphaFold DB A0A808XYT1

References