Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4880637..4881153 Replicon chromosome
Accession NZ_CP067060
Organism Klebsiella pneumoniae strain ZJ27003

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag JE026_RS23430 Protein ID WP_004178374.1
Coordinates 4880637..4880921 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JE026_RS23435 Protein ID WP_002886901.1
Coordinates 4880911..4881153 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JE026_RS23405 (4876033) 4876033..4876296 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
JE026_RS23410 (4876426) 4876426..4876599 + 174 WP_041169004.1 hypothetical protein -
JE026_RS23415 (4876602) 4876602..4877345 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
JE026_RS23420 (4877702) 4877702..4879840 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
JE026_RS23425 (4880169) 4880169..4880633 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JE026_RS23430 (4880637) 4880637..4880921 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JE026_RS23435 (4880911) 4880911..4881153 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JE026_RS23440 (4881231) 4881231..4883141 - 1911 WP_012737231.1 PRD domain-containing protein -
JE026_RS23445 (4883164) 4883164..4884318 - 1155 WP_012737230.1 lactonase family protein -
JE026_RS23450 (4884385) 4884385..4885125 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T185668 WP_004178374.1 NZ_CP067060:c4880921-4880637 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T185668 NZ_CP088988:c5296046-5295663 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCAGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT185668 WP_002886901.1 NZ_CP067060:c4881153-4880911 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT185668 NZ_CP088988:c5296288-5296046 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References