Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 797657..798314 Replicon chromosome
Accession NZ_CP067060
Organism Klebsiella pneumoniae strain ZJ27003

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag JE026_RS03960 Protein ID WP_002916310.1
Coordinates 797904..798314 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag JE026_RS03955 Protein ID WP_002916312.1
Coordinates 797657..797923 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JE026_RS03930 (792865) 792865..794298 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
JE026_RS03935 (794417) 794417..795145 - 729 WP_048336809.1 MurR/RpiR family transcriptional regulator -
JE026_RS03940 (795195) 795195..795506 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
JE026_RS03945 (795670) 795670..796329 + 660 WP_002916317.1 hemolysin III family protein -
JE026_RS03950 (796428) 796428..797411 - 984 WP_014906951.1 tRNA-modifying protein YgfZ -
JE026_RS03955 (797657) 797657..797923 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
JE026_RS03960 (797904) 797904..798314 + 411 WP_002916310.1 protein YgfX Toxin
JE026_RS03965 (798321) 798321..798842 - 522 WP_002916308.1 flavodoxin FldB -
JE026_RS03970 (798943) 798943..799839 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
JE026_RS03975 (799862) 799862..800575 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JE026_RS03980 (800581) 800581..802314 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T185656 WP_002916310.1 NZ_CP067060:797904-798314 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T185656 NZ_CP088987:c78310-77828 [Klebsiella pneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCACTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGAAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCTACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGTGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGCGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT185656 WP_002916312.1 NZ_CP067060:797657-797923 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT185656 NZ_CP088987:c78564-78298 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGTACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGATTCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References