Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-couple_hipB |
| Location | 345980..347799 | Replicon | plasmid pPlas2 |
| Accession | NZ_CP067059 | ||
| Organism | Rahnella aceris strain ZF458 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | - |
| Locus tag | JHW33_RS25000 | Protein ID | WP_200227639.1 |
| Coordinates | 345980..347329 (+) | Length | 450 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | H8P0A0 |
| Locus tag | JHW33_RS25005 | Protein ID | WP_013578106.1 |
| Coordinates | 347326..347799 (+) | Length | 158 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JHW33_RS24965 | 341383..341592 | - | 210 | Protein_321 | iron dicitrate ABC transporter ATP-binding protein | - |
| JHW33_RS24970 | 341867..342085 | - | 219 | WP_013578112.1 | YgdI/YgdR family lipoprotein | - |
| JHW33_RS24975 | 342464..342838 | + | 375 | WP_200227633.1 | hypothetical protein | - |
| JHW33_RS24980 | 342951..344276 | + | 1326 | WP_200227635.1 | heme anaerobic degradation radical SAM methyltransferase ChuW/HutW | - |
| JHW33_RS24985 | 344254..344775 | + | 522 | WP_165497365.1 | heme utilization cystosolic carrier protein HutX | - |
| JHW33_RS24990 | 344772..345395 | + | 624 | WP_200227637.1 | NAD(P)H-binding protein | - |
| JHW33_RS24995 | 345563..345784 | + | 222 | WP_014416648.1 | DUF1471 domain-containing protein | - |
| JHW33_RS25000 | 345980..347329 | + | 1350 | WP_200227639.1 | HipA domain-containing protein | Toxin |
| JHW33_RS25005 | 347326..347799 | + | 474 | WP_013578106.1 | helix-turn-helix domain-containing protein | Antitoxin |
| JHW33_RS25010 | 347859..348179 | - | 321 | WP_013578105.1 | multidrug efflux SMR transporter | - |
| JHW33_RS25015 | 348295..349149 | - | 855 | WP_200227641.1 | LysR family transcriptional regulator | - |
| JHW33_RS25020 | 349346..350845 | - | 1500 | WP_013578103.1 | UbiD family decarboxylase | - |
| JHW33_RS25025 | 351093..352559 | - | 1467 | WP_200227643.1 | HAMP domain-containing histidine kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | blaRAHN-2 | hcp/tssD / vipB/tssC / vipA/tssB / mgtB / clpB / AHA_1833 / AHA_1832 / hcp1 / hcp/tssD | 1..553387 | 553387 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 450 a.a. Molecular weight: 51306.86 Da Isoelectric Point: 4.7931
>T185652 WP_200227639.1 NZ_CP067059:345980-347329 [Rahnella aceris]
MEFLTLQAFLNNTWVDIANITFPGSEQNNYRLTELNYHSDYAIDNLDRDDNHAASLNHPVSLFFDGDDERGWLKFLDDII
PSGSSRRYWANYLDLEGLTADQQNFILLKHGTLSPVGNLRIKESLPEYNPLAEKLFFTIEDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLLLRCSQEQQIWIDTYQNDTANRDIPYLVKYPRGARTEVDCNILRAEFYFYHELEAMGFDTIPTQNMR
LEEGLTYPSLWLPRFDISFEEEGLIRRFGMESVYSLLRKAPGVTLYHEETLRALIDKISHSHMVTEQGFDFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTSFLKDERSIRLAPIYDFAPMKADPEGIVRTTKWKAPLEIGGEYDYPGIAQSLDDLVPAET
LLSALKNTSHQLSGLKKRLEARGIPQQILNMPAMSFSFIPEKLRRWGLL
MEFLTLQAFLNNTWVDIANITFPGSEQNNYRLTELNYHSDYAIDNLDRDDNHAASLNHPVSLFFDGDDERGWLKFLDDII
PSGSSRRYWANYLDLEGLTADQQNFILLKHGTLSPVGNLRIKESLPEYNPLAEKLFFTIEDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLLLRCSQEQQIWIDTYQNDTANRDIPYLVKYPRGARTEVDCNILRAEFYFYHELEAMGFDTIPTQNMR
LEEGLTYPSLWLPRFDISFEEEGLIRRFGMESVYSLLRKAPGVTLYHEETLRALIDKISHSHMVTEQGFDFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTSFLKDERSIRLAPIYDFAPMKADPEGIVRTTKWKAPLEIGGEYDYPGIAQSLDDLVPAET
LLSALKNTSHQLSGLKKRLEARGIPQQILNMPAMSFSFIPEKLRRWGLL
Download Length: 1350 bp
>T185652 NZ_CP088985:c4493063-4492779 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCTGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCTGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
Antitoxin
Download Length: 158 a.a. Molecular weight: 17587.18 Da Isoelectric Point: 10.9653
>AT185652 WP_013578106.1 NZ_CP067059:347326-347799 [Rahnella aceris]
MKEPEIAANSARNTIDKIRAKQNEANHVRRDAGQMLAQEETSSTGKKQAQRRVSNLTKPVSTNDRNQARLDIMRALLLGE
ITQGQALKALRITVLGLKQDAFGKLVTVSRKTLSEVENDKGNYTPDIINKLFRPFGLKVGLVPVSQQIFRTLFERSE
MKEPEIAANSARNTIDKIRAKQNEANHVRRDAGQMLAQEETSSTGKKQAQRRVSNLTKPVSTNDRNQARLDIMRALLLGE
ITQGQALKALRITVLGLKQDAFGKLVTVSRKTLSEVENDKGNYTPDIINKLFRPFGLKVGLVPVSQQIFRTLFERSE
Download Length: 474 bp
>AT185652 NZ_CP088985:c4493295-4493053 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|