Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 28821..29398 Replicon plasmid pPlas1
Accession NZ_CP067058
Organism Rahnella aceris strain ZF458

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag JHW33_RS22575 Protein ID WP_200227514.1
Coordinates 29066..29398 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag JHW33_RS22570 Protein ID WP_037035624.1
Coordinates 28821..29066 (+) Length 82 a.a.

Genomic Context

JHW33_RS22555JHW33_RS22560JHW33_RS22565JHW33_RS22570JHW33_RS22575JHW33_RS22580JHW33_RS22585
Location: 23967..27215 (3249 bp)
Type: Others
Protein ID: WP_200227508.1
Location: 27231..27809 (579 bp)
Type: Others
Protein ID: WP_200227510.1
Location: 27937..28671 (735 bp)
Type: Others
Protein ID: WP_200227512.1
Location: 28821..29066 (246 bp)
Type: Antitoxin
Protein ID: WP_037035624.1
Location: 29066..29398 (333 bp)
Type: Toxin
Protein ID: WP_200227514.1
Location: 29617..29952 (336 bp)
Type: Others
Protein ID: WP_200227516.1
Location: 30059..32734 (2676 bp)
Type: Others
Protein ID: WP_200227518.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
JHW33_RS2255523967..27215+3249WP_200227508.1conjugal transfer mating pair stabilization protein TraG-
JHW33_RS2256027231..27809+579WP_200227510.1hypothetical protein-
JHW33_RS2256527937..28671+735WP_200227512.1complement resistance protein TraT-
JHW33_RS2257028821..29066+246WP_037035624.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
JHW33_RS2257529066..29398+333WP_200227514.1endoribonuclease MazFToxin
JHW33_RS2258029617..29952+336WP_200227516.1hypothetical protein-
JHW33_RS2258530059..32734+2676WP_200227518.1type IV conjugative transfer system coupling protein TraD-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..188256188256


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-107)

Antitoxin

SpoVT-AbrB domain

(7-48)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11951.70 Da        Isoelectric Point: 7.1334

>T185648 WP_200227514.1 NZ_CP067058:29066-29398 [Rahnella aceris]
MVSRFVPDSGDLIWIDFDPVAGHEQGGHRPAVVLSPFAYNNKVGLLLCVPCTTQVKNYPFEVELSGSREGVALADQVTSV
DWRARKITQKGTVAVNELAEIRAKAKSLIG

Download         Length: 333 bp

>T185648 NZ_CP088985:c2501345-2500023 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGGACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACTCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8713.15 Da        Isoelectric Point: 5.0022

>AT185648 WP_037035624.1 NZ_CP067058:28821-29066 [Rahnella aceris]
MAQVIVKKWGNSPSVRLPVAIMKAASLNIDDTVEIVVEEGRIIIVPTRVKEYSLDALLAGISADNIHDKADFGAPTGKEL
L

Download         Length: 246 bp

>AT185648 NZ_CP088985:c2501611-2501345 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGATGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATCACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
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Antitoxin

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Source
ID
Structure
No matching records found

References