Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4472189..4472888 Replicon chromosome
Accession NZ_CP067057
Organism Rahnella aceris strain ZF458

Toxin (Protein)


Gene name cptA Uniprot ID A0A0H3F674
Locus tag JHW33_RS20540 Protein ID WP_013574109.1
Coordinates 4472436..4472888 (+) Length 151 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag JHW33_RS20535 Protein ID WP_037035260.1
Coordinates 4472189..4472455 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JHW33_RS20505 4467196..4467531 + 336 WP_013574102.1 DUF2002 family protein -
JHW33_RS20510 4467596..4468483 - 888 WP_200224112.1 AraC family transcriptional regulator -
JHW33_RS20515 4468610..4469050 - 441 WP_013574104.1 DUF1198 domain-containing protein -
JHW33_RS20520 4469210..4470154 - 945 WP_037035220.1 6-phosphofructokinase II -
JHW33_RS20525 4470339..4470869 + 531 WP_013574106.1 class IV adenylate cyclase -
JHW33_RS20530 4470918..4471910 - 993 WP_013574107.1 tRNA-modifying protein YgfZ -
JHW33_RS20535 4472189..4472455 + 267 WP_037035260.1 FAD assembly factor SdhE Antitoxin
JHW33_RS20540 4472436..4472888 + 453 WP_013574109.1 protein YgfX Toxin
JHW33_RS20545 4472934..4473452 - 519 WP_013574110.1 flavodoxin FldB -
JHW33_RS20550 4473552..4474511 + 960 WP_072012276.1 site-specific tyrosine recombinase XerD -
JHW33_RS20555 4474537..4475256 + 720 WP_200227290.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JHW33_RS20560 4475263..4476996 + 1734 WP_200224114.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-140)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 151 a.a.        Molecular weight: 17573.93 Da        Isoelectric Point: 11.8346

>T185647 WP_013574109.1 NZ_CP067057:4472436-4472888 [Rahnella aceris]
VALWRCDLRVSWRSQLISLGCYGAVMLLILLAPWPAGYWPVWMTLLLLVLFECIRSQRRITARTGEMILLEDNRLLWRGH
EWQIKQPVWMISHGVLLSLRREKRKGGLAQAMRSSRQRLWLASDSMSLEEWRRLRQILLSGTPRSPVKPG

Download         Length: 453 bp

>T185647 NZ_CP088985:1823087-1823189 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10464.97 Da        Isoelectric Point: 5.1236

>AT185647 WP_037035260.1 NZ_CP067057:4472189-4472455 [Rahnella aceris]
MDINNRSRVHWACRRGMRELDISIMPFFEYEYDSLSETDKEVFVRLLTCDDPDLFNWLMNHGEPKDTELQRMVALIQTRN
KARGPVAM

Download         Length: 267 bp

>AT185647 NZ_CP088985:c1823196-1823051 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3F674

Antitoxin

Source ID Structure

References