Detailed information of TA system TA185645

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 3677401..3677923
• Replicon: chromosome
• Accession: NZ_CP067057
• Organism: Rahnella aceris strain ZF458

Toxin (Protein)

• Gene name: relE
• Uniprot ID: H8NLY9
• Locus tag: JHW33_RS16755
• Protein ID: WP_013573377.1
• Coordinates: 3677639..3677923 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: H8NLY8
• Locus tag: JHW33_RS16750
• Protein ID: WP_013573376.1
• Coordinates: 3677401..3677649 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JHW33_RS16730	3673229..3673891	-	663	WP_037033864.1	OmpA family lipoprotein	-
JHW33_RS16735	3674113..3674556	-	444	WP_013573373.1	N-acetyltransferase	-
JHW33_RS16740	3674553..3675125	-	573	WP_200223530.1	DNA-3-methyladenine glycosylase I	-
JHW33_RS16745	3675316..3677322	+	2007	WP_200223540.1	autotransporter domain-containing protein	-
JHW33_RS16750	3677401..3677649	+	249	WP_013573376.1	plasmid stabilization protein	Antitoxin
JHW33_RS16755	3677639..3677923	+	285	WP_013573377.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JHW33_RS16760	3678045..3678980	+	936	WP_037033860.1	glycine--tRNA ligase subunit alpha	-
JHW33_RS16765	3678988..3681057	+	2070	WP_037033908.1	glycine--tRNA ligase subunit beta	-
JHW33_RS16770	3681342..3682064	+	723	WP_134706454.1	DUF3053 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10954.92 Da
• Isoelectric Point: 10.5358

>T185645 WP_013573377.1 NZ_CP067057:3677639-3677923 [Rahnella aceris]
MTYKLNFFKSALKEWKALAPTIKEQFKKKLAERLENPHVVSARLCGPKNNRYKIKLKSLGYRLVYQVEDQEIIVTVVAVG
KREGNEAYKLAEKR

Nucleotide

• Length: 285 bp

>T185645 NZ_CP088985:363152-363499 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATTCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGAGCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9155.35 Da
• Isoelectric Point: 3.9951

>AT185645 WP_013573376.1 NZ_CP067057:3677401-3677649 [Rahnella aceris]
MPFEILTSSAASITELKRDPMGTFSAGEGEAVAILNRNEPAFYCVPPDVYAYFLSLAEDVELNRIMDARQGEERIRLTLD
DL

Nucleotide

• Length: 249 bp

>AT185645 NZ_CP088985:363499-363798 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Structures

Toxin

• AlphaFold DB: H8NLY9

Antitoxin

• AlphaFold DB: H8NLY8