Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 327162..328078 Replicon chromosome
Accession NZ_CP067057
Organism Rahnella aceris strain ZF458

Toxin (Protein)


Gene name - Uniprot ID H8NRM1
Locus tag JHW33_RS01435 Protein ID WP_013574722.1
Coordinates 327162..327620 (-) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID H2IQN3
Locus tag JHW33_RS01440 Protein ID WP_013574723.1
Coordinates 327617..328078 (-) Length 154 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JHW33_RS01410 322745..324430 + 1686 WP_013574717.1 choline dehydrogenase -
JHW33_RS01415 324521..324988 + 468 WP_037036100.1 GNAT family N-acetyltransferase -
JHW33_RS01420 325213..326142 - 930 WP_200224978.1 LysR family transcriptional regulator -
JHW33_RS01425 326244..326678 + 435 WP_013574720.1 DMT family transporter -
JHW33_RS01430 326682..327134 + 453 WP_200224979.1 DMT family transporter -
JHW33_RS01435 327162..327620 - 459 WP_013574722.1 RES family NAD+ phosphorylase Toxin
JHW33_RS01440 327617..328078 - 462 WP_013574723.1 DUF2384 domain-containing protein Antitoxin
JHW33_RS01445 328429..329316 + 888 WP_037036097.1 nucleoside-specific channel-forming protein Tsx -
JHW33_RS01450 329503..331095 + 1593 WP_015696564.1 ABC-F family ATPase -
JHW33_RS01455 331278..332039 - 762 WP_134706103.1 molybdopterin-synthase adenylyltransferase MoeB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-136)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(34-95)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 16974.55 Da        Isoelectric Point: 4.7091

>T185634 WP_013574722.1 NZ_CP067057:c327620-327162 [Rahnella aceris]
MKLFRIVQTRHLATAWSGAGAQLYGGRWNPPGRPVVYVTTSISLAILEILVHLQNSMLMRSYTLLSIEVPEELLDTLEVS
ELAADWRSASVPDSTQRQGDVWLAEGEYVGLKVPSVIVPSEYNVLLNPLHPAFADLLSSVEREPMMFDPRLQ

Download         Length: 459 bp

>T185634 NZ_CP088982:c2803295-2801973 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGAGGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCTCTCTCACTGCCGCTGCAGTATGGCAATATCACGG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAA
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTTACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCGGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTTTCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 154 a.a.        Molecular weight: 16505.80 Da        Isoelectric Point: 7.0196

>AT185634 WP_013574723.1 NZ_CP067057:c328078-327617 [Rahnella aceris]
MNSKITGLSSSSVQDSATPLWQSAGLPASSGISLINAIQKGFPVDSISRLNTELGWPKMVLLEIMGINERNYARRKAGNG
LLKSEESERVARLVRIVDAATDLFEGDRVSALEWFTRPAPALDGSRPLELLSSEAGAVEVSRLIGRLQHGVFS

Download         Length: 462 bp

>AT185634 NZ_CP088982:c2803561-2803295 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H8NRM1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3F7Y1

References