Detailed information of TA system TA185633

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 51608..52453
• Replicon: chromosome
• Accession: NZ_CP067057
• Organism: Rahnella aceris strain ZF458

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: JHW33_RS00270
• Protein ID: WP_200224639.1
• Coordinates: 51608..52009 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: JHW33_RS00275
• Protein ID: WP_200224653.1
• Coordinates: 52085..52453 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JHW33_RS00245	46834..48372	+	1539	WP_013574506.1	MFS transporter	-
JHW33_RS00250	48415..48942	-	528	WP_037036282.1	GNAT family N-acetyltransferase	-
JHW33_RS00255	49177..49995	+	819	WP_037036274.1	lipoprotein NlpA	-
JHW33_RS00260	50269..51106	-	838	Protein_51	DUF4942 domain-containing protein	-
JHW33_RS00265	51184..51540	-	357	WP_200227126.1	hypothetical protein	-
JHW33_RS00270	51608..52009	-	402	WP_200224639.1	TA system toxin CbtA family protein	Toxin
JHW33_RS00275	52085..52453	-	369	WP_200224653.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
JHW33_RS00280	52509..52715	-	207	WP_200224661.1	hypothetical protein	-
JHW33_RS00285	52725..53174	-	450	WP_200224668.1	DNA repair protein RadC	-
JHW33_RS00290	53460..53894	-	435	WP_200224674.1	hypothetical protein	-
JHW33_RS00295	54216..55037	-	822	WP_200224681.1	DUF945 domain-containing protein	-
JHW33_RS00300	55047..55670	-	624	WP_200224688.1	EcsC family protein	-
JHW33_RS00305	55800..56864	-	1065	WP_200224695.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (13-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14927.77 Da
• Isoelectric Point: 6.4639

>T185633 WP_200224639.1 NZ_CP067057:c52009-51608 [Rahnella aceris]
MKTSTSAAPSAVPVSSSPSPVAVWRQLLTYLFDRHYGLTLNDTPFHYESVIEEYIDAGISLKDAVNFVAERYGLLRIDCS
SFSLTEQPQFISYVNILQARRATGLMQQEGYKEISVLTQGKRTTEGRTNENSR

Nucleotide

• Length: 402 bp

>T185633 NZ_CP088982:2091798-2091900 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13547.56 Da
• Isoelectric Point: 6.9558

>AT185633 WP_200224653.1 NZ_CP067057:c52453-52085 [Rahnella aceris]
MTLPLLPATQPTVAPARPQWGLRHDIPPCFGARLVQESSRLYFLVDRAGFCGAFSADDALRIDQAFPLILKQLERMLVTG
ELNPRHQQRVTLHHNGLTCDADPLGSHGYVYLSIYPTPPAET

Nucleotide

• Length: 369 bp

>AT185633 NZ_CP088982:c2091907-2091762 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT