Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4087246..4087865 Replicon chromosome
Accession NZ_CP067045
Organism Klebsiella pneumoniae strain B6753

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag IL988_RS20145 Protein ID WP_002892050.1
Coordinates 4087647..4087865 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag IL988_RS20140 Protein ID WP_002892066.1
Coordinates 4087246..4087620 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IL988_RS20130 (4082398) 4082398..4083591 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
IL988_RS20135 (4083614) 4083614..4086760 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
IL988_RS20140 (4087246) 4087246..4087620 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
IL988_RS20145 (4087647) 4087647..4087865 + 219 WP_002892050.1 HHA domain-containing protein Toxin
IL988_RS20150 (4088024) 4088024..4088590 + 567 WP_002892030.1 maltose O-acetyltransferase -
IL988_RS20155 (4088562) 4088562..4088702 - 141 WP_004147370.1 hypothetical protein -
IL988_RS20160 (4088723) 4088723..4089193 + 471 WP_002892026.1 YlaC family protein -
IL988_RS20165 (4089168) 4089168..4090619 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
IL988_RS20170 (4090720) 4090720..4091418 + 699 WP_002892021.1 GNAT family protein -
IL988_RS20175 (4091415) 4091415..4091555 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
IL988_RS20180 (4091555) 4091555..4091818 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T185627 WP_002892050.1 NZ_CP067045:4087647-4087865 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T185627 NZ_CP088980:1235907-1236083 [Rhodanobacter denitrificans]
ATGAAGTACAGCGAGTTCCAGCGGTGGCTCAGGCAGCAGGGAGTGAGCTTCGAGCCCGGCAAGGGCAGCCACCAGCTGGC
GCGCTACAGAGGCCGGACTTCCGTCTTTCCCTTCCACGGATCGAAAGAGATGCCCGAGCCGCTGCGCAAGAAGATCCTGA
AGGACCTGGGTCTTTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT185627 WP_002892066.1 NZ_CP067045:4087246-4087620 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT185627 NZ_CP088980:1236116-1236535 [Rhodanobacter denitrificans]
ATGAAATACCCCGTCAAGCTGACCCGTGCCGATAGCGTGGTGATGGTGACCTGCCCGGACCTGCCGGAGTTTTCCAGCGT
CGGCGACACCGAGGGCGAGGCTCTGCGCGAAGCCGTCGACGGTATCGAAACCACGCTGCAGGCGTACATGCAGGACCGGC
GTGACATTCCGCCGCCGGGCGCGCGCAAGCGCGGCCAGCGGCTGGTGGAGCTGCCGCCGCTGGCGGTGGCCAAGCTCGGT
CTGTACCGGGCCATGCGCGAACAGGGGTTGCGCAAGGCTGACCTGGCCCGCCGGCTCGACGTGCATCTGCCCCAGGTCGA
CCGCCTGCTCGACCTGCGCCACAGCTCGAAGCTGGAACAGGTGGAGGCGGCGCTCAACGCGTTGGGCTACCGGATCGAAC
TGGCGGTGCTGGCGGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References