Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 646956..647593 Replicon chromosome
Accession NZ_CP067043
Organism Bacillus velezensis strain 19573-3

Toxin (Protein)


Gene name mazF Uniprot ID G4NU33
Locus tag JHX84_RS03330 Protein ID WP_003156187.1
Coordinates 646956..647306 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID I2HMS5
Locus tag JHX84_RS03335 Protein ID WP_003156188.1
Coordinates 647312..647593 (-) Length 94 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JHX84_RS03290 (JHX84_03290) 641996..642598 - 603 WP_003156170.1 PP2C family serine/threonine-protein phosphatase -
JHX84_RS03295 (JHX84_03295) 642598..643386 - 789 WP_003156171.1 RNA polymerase sigma factor SigB -
JHX84_RS03300 (JHX84_03300) 643352..643834 - 483 WP_161503396.1 anti-sigma B factor RsbW -
JHX84_RS03305 (JHX84_03305) 643831..644160 - 330 WP_003156176.1 anti-sigma factor antagonist RsbV -
JHX84_RS03310 (JHX84_03310) 644224..645231 - 1008 WP_003156177.1 PP2C family protein-serine/threonine phosphatase -
JHX84_RS03315 (JHX84_03315) 645243..645644 - 402 WP_003156178.1 anti-sigma regulatory factor -
JHX84_RS03320 (JHX84_03320) 645647..646012 - 366 WP_003156180.1 RsbT antagonist protein RsbS -
JHX84_RS03325 (JHX84_03325) 646017..646838 - 822 WP_003156182.1 STAS domain-containing protein -
JHX84_RS03330 (JHX84_03330) 646956..647306 - 351 WP_003156187.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
JHX84_RS03335 (JHX84_03335) 647312..647593 - 282 WP_003156188.1 type II toxin-antitoxin system antitoxin EndoAI Antitoxin
JHX84_RS03340 (JHX84_03340) 647713..648882 - 1170 WP_003156189.1 alanine racemase -
JHX84_RS03345 (JHX84_03345) 648999..650006 - 1008 WP_003156191.1 outer membrane lipoprotein carrier protein LolA -
JHX84_RS03350 (JHX84_03350) 650171..650536 - 366 WP_003156192.1 holo-ACP synthase -
JHX84_RS03355 (JHX84_03355) 650629..651228 + 600 WP_003156193.1 rhomboid family intramembrane serine protease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-111)

Antitoxin

(12-45)


Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8781

>T185612 WP_003156187.1 NZ_CP067043:c647306-646956 [Bacillus velezensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF

Download         Length: 351 bp

>T185612 NZ_CP088966:81150-81443 [Brucella anthropi]
ATGGAATTTAAACTCTCTGTTCTTGCGGAAGACGATATCATTGCTATCGCCGAGCAGGGTATAGCAATGTTTGGGCCTGT
GCAGGCGAAACGCTATCATGCAGAGTTGTTTAACACTCTGGATTTAATTGCAAAGAACCCACAAATGGCACGTGCACGTG
AAGAAATTTCTCCACCTGTGCGGGTGCACCCGTTTAAAGCCCACCTCATTATTTATCAAATTGAAGCAGACGGAACAGTT
TTTGTAATTCGGGTACGTCATGCATTTGAAGATTGGGTCAGGGATCCGTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10562.92 Da        Isoelectric Point: 6.4706

>AT185612 WP_003156188.1 NZ_CP067043:c647593-647312 [Bacillus velezensis]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHYAEC
EAETTVERLVSGG

Download         Length: 282 bp

>AT185612 NZ_CP088966:80896-81150 [Brucella anthropi]
ATGGTAACGATGAACGTATCGCTCCCTCATCCTATGAAAGAATGGGTTGAGGCTCAGGCCAAAACGGGACGCTATTCGAA
TGCGAGTGACTATGTGCGCGATTTGATCCGTAAAGATCAAATGCGCAGCGATAAGATCGCAGCGATGCAGCGCTTTGTTG
ACGAGGGCTTACAAAGTGGCCCAGGAAGTCGTTCACAGGATGAACTCTTCGCAGTGGCACTCGCTAACGCCGAAAAATCT
CTGAAACGCAACTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4MDX
PDB 4ME7
PDB 1NE8


Antitoxin

Source ID Structure
AlphaFold DB I2HMS5

References