185597

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 352711..353191 Replicon chromosome
Accession NZ_CP067027
Organism Agrobacterium fabrum strain GV2260

Toxin (Protein)


Gene name pasB Uniprot ID A9CK22
Locus tag EML4058_RS01755 Protein ID WP_010971059.1
Coordinates 352711..352980 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A9CK21
Locus tag EML4058_RS01760 Protein ID WP_010971060.1
Coordinates 352964..353191 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EML4058_RS01725 347762..348538 - 777 WP_010971054.1 L,D-transpeptidase -
EML4058_RS01730 348777..349406 + 630 WP_010971055.1 DNA-3-methyladenine glycosylase I -
EML4058_RS01735 349403..349846 + 444 WP_010972617.1 hypothetical protein -
EML4058_RS01740 349872..350915 - 1044 WP_035256280.1 YeiH family protein -
EML4058_RS01745 350997..351914 + 918 WP_010971057.1 LysR family transcriptional regulator -
EML4058_RS01750 351940..352704 - 765 WP_010971058.1 hypothetical protein -
EML4058_RS01755 352711..352980 - 270 WP_010971059.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EML4058_RS01760 352964..353191 - 228 WP_010971060.1 ribbon-helix-helix protein, CopG family Antitoxin
EML4058_RS01765 353348..354871 + 1524 WP_010971061.1 histidine--tRNA ligase -
EML4058_RS01770 354876..355244 + 369 WP_010971062.1 VOC family protein -
EML4058_RS01775 355261..356388 + 1128 WP_010971063.1 ATP phosphoribosyltransferase regulatory subunit -
EML4058_RS01780 356385..357077 + 693 WP_010971064.1 ATP phosphoribosyltransferase -
EML4058_RS01785 357142..357588 - 447 WP_006313161.1 DoxX family protein -
EML4058_RS01790 357744..358178 - 435 WP_010971066.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-88)

Antitoxin

Protein of unknown function DUF6290

(6-73)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10746.46 Da        Isoelectric Point: 9.9414

>T185597 WP_010971059.1 NZ_CP067027:c352980-352711 [Agrobacterium fabrum]
VIWTIEYHTLVQKEMRKINPEVRRRIRSFLHERLAALDDPRQIGATLQGSELGNFWRYRVGDYRIICDIQDQKLVVLVVE
IGHRREIYR

Download         Length: 270 bp

>T185597 NZ_CP088935:535600-535791 [Thauera sp. WB-2]
ATGACTGAGCTTGCCGCCCTGAAGGCCCGCATCCTGGCGAACCCCTACACCCGCGCAATGGGTGATGGGCTGTTCGAGAT
TCGCGCCAAGGGGCAGGAAGGCATCGGACGCGCCTTGTTCTGCACAGTCGTCGGCAAGCGCATCGTCCAGCCCTTGCCGA
GCTGCTGCGCGCCCGCCAGCGTGCCGGCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8937.97 Da        Isoelectric Point: 4.7254

>AT185597 WP_010971060.1 NZ_CP067027:c353191-352964 [Agrobacterium fabrum]
MSKQTAIRLPDETYERLKALSERTGRTSAYYIREAIEKHIEDMEDLYLAEEATRRIQRGESKIISAEEFWRDLDN

Download         Length: 228 bp

>AT185597 NZ_CP088935:535803-535967 [Thauera sp. WB-2]
TTGGCCGAGCGCATGGGTGTGTCGCAGCCTGTCGTGGCCCGCATCGAGGGCAGCATCGGCAGTCGCAAGCACGCCCCTTC
CCTGGCGACCTTGCGCAAGTACGCGGACGCCTGCGGGCAGAGGTTGGTGATTCGCTTCGAGCCAAAGCAAGAGCACGCGG
CCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A9CK22

Antitoxin

Source ID Structure
AlphaFold DB A9CK21

References