Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4464564..4465186 Replicon chromosome
Accession NZ_CP067024
Organism Pseudomonas syringae pv. maculicola strain MAFF 302723

Toxin (Protein)


Gene name hicA Uniprot ID Q886E5
Locus tag JHZ65_RS19885 Protein ID WP_011103638.1
Coordinates 4465004..4465186 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q886E4
Locus tag JHZ65_RS19880 Protein ID WP_005767619.1
Coordinates 4464564..4464968 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JHZ65_RS19865 4460334..4461002 + 669 WP_005767626.1 ABC transporter ATP-binding protein -
JHZ65_RS19870 4461002..4463479 + 2478 WP_122388795.1 ABC transporter permease -
JHZ65_RS19875 4463469..4464548 + 1080 WP_046463929.1 iron ABC transporter permease -
JHZ65_RS19880 4464564..4464968 - 405 WP_005767619.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JHZ65_RS19885 4465004..4465186 - 183 WP_011103638.1 type II toxin-antitoxin system HicA family toxin Toxin
JHZ65_RS19890 4465471..4467243 + 1773 WP_007245686.1 N-acetylglutaminylglutamine amidotransferase -
JHZ65_RS19895 4467247..4468995 + 1749 WP_044392447.1 N-acetylglutaminylglutamine synthetase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6675.81 Da        Isoelectric Point: 10.6643

>T185591 WP_011103638.1 NZ_CP067024:c4465186-4465004 [Pseudomonas syringae pv. maculicola]
VQSRQLVKELEADGWVLDRVTGSHHMFKHPEKSQTVPVPHPKKDLPLGTVKAIRKLAGLA

Download         Length: 183 bp

>T185591 NZ_CP088924:c119206-118910 [Rhodanobacter thiooxydans]
ATGGAGAAACGCACGCCTCATTGCCAGCTGGCCGTCGTGAAGACCTTGATTGCCGACGGCAAGGTGCGATCTACGTTCTC
GGCCCTGACTGGCGGTGCTGCCTTGGGCTTCGACTTTGACGGCATCGTCAGCGTGGTTGCCTCGCTGACCCCGAAGGATT
TCTACAAGAGCATGACTACGCATGCGGATCATCGGGTGTGGCAAGACGTGTACCGGCCCAGCACGTCCGCTGGCGAGGTC
TACCTGAAACTGACGGTCATCGATGACGTGCTCATCGTGTCCTTCAAGGAGCTTTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14455.52 Da        Isoelectric Point: 4.9093

>AT185591 WP_005767619.1 NZ_CP067024:c4464968-4464564 [Pseudomonas syringae pv. maculicola]
MKYPICIEWGDETTAFGIQIPDIPGAITAGDTFEEAHAAAVEIAHIMLQEIAASGGSIPKVGTVAEHAKNPDFSGMGWGM
LEIDVTPYLGKTEKVNVTLPGFVIRQIDRYVRDHSIKSRSTFLADAALEKLGRA

Download         Length: 405 bp

>AT185591 NZ_CP088924:c118907-118506 [Rhodanobacter thiooxydans]
ATGAAATGTCCATCGTGTGCAGGCGCGGAACTGGTGCGAGACACCCGCGACCTGCCCTATACCTACAAGGGCGAATCGAC
CCTCATTCCGAGCGTCACGGGTGACTTCTGCCCGATCTGCGGGGAAATGATCCTAGATGTTGCCGAGTCGGTACGAACCA
GTGCGGTGATGCTGGATTTCAACAAACAGGTGAATGCCTCAATCGTCGATCCCAGTTTCATCGCCAGCGTCCGAAAGAAG
CTGGCACTCGACCAACGCGAAGCGGCCGAGATCTTCGGCGGTGGCGTCAATGCGTTCTCGCGGTACGAAACCGGCAAGAC
CAAGCCCCCGCTGGCGCTAGTGAAGTTGCTCAAGGTGCTTGATCGTCATCCTGACCTGTTGAATGAAGTGAGGGCGGCCT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q886E5

Antitoxin

Source ID Structure
AlphaFold DB A0A3M3Z2W9

References