Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 5642273..5642912 Replicon chromosome
Accession NZ_CP067022
Organism Pseudomonas cannabina pv. alisalensis strain MAFF 301419

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag JGS08_RS25090 Protein ID WP_007252702.1
Coordinates 5642730..5642912 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A8T8C7U3
Locus tag JGS08_RS25085 Protein ID WP_054079873.1
Coordinates 5642273..5642698 (-) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGS08_RS25070 5638744..5640066 + 1323 WP_054079875.1 murein hydrolase activator EnvC -
JGS08_RS25075 5640100..5641431 + 1332 WP_007252705.1 S41 family peptidase -
JGS08_RS25080 5641435..5642217 + 783 WP_054079874.1 divergent polysaccharide deacetylase family protein -
JGS08_RS25085 5642273..5642698 - 426 WP_054079873.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
JGS08_RS25090 5642730..5642912 - 183 WP_007252702.1 type II toxin-antitoxin system HicA family toxin Toxin
JGS08_RS25095 5643230..5644744 + 1515 WP_007252701.1 serine protease -
JGS08_RS25100 5644725..5645480 - 756 WP_007252700.1 ABC transporter substrate-binding protein -
JGS08_RS25105 5645668..5646438 - 771 WP_002551458.1 imidazole glycerol phosphate synthase subunit HisF -
JGS08_RS25110 5646458..5647195 - 738 WP_007252699.1 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase -
JGS08_RS25115 5647301..5647561 - 261 WP_007252698.1 DUF2164 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-58)

Antitoxin

DNA binding HTH domain, Psq-type

(86-112)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6850.95 Da        Isoelectric Point: 10.6211

>T185588 WP_007252702.1 NZ_CP067022:c5642912-5642730 [Pseudomonas cannabina pv. alisalensis]
MKCSEFRRWLQAQGAEFRAAKGSHFKVYLNGKATIFADHGSKEMHEGLRKSIIKQLGLKD

Download         Length: 183 bp

>T185588 NZ_CP088923:1725592-1726002 [Rhodanobacter thiooxydans]
ATGAGCGCTAAGGCGTTCATCGACAGCAATATCGTGCTGTACCTGTTGTCGGCGGACACCGGCAAGGCCGATCGCGCCGA
GGCCGTGATCGCGGCTGGTGGCGTGGTCAGCGTGCAGGTGTTGAACGAAGTGACCAGCGTCGCCCGGCGCAAACTGGGCA
TGAGCTGGAGCGAGACCGCCGAAGTGCTCGCCGGGTTGCGCGCCGTCTGCCCGGTGGAGTCATTGACCGCCGATACCCAT
GACACCGGGCGGCGGCTGGCGGAGCGGTACGGCTTGTCGGTGTACGACGCGATGATTGCCTCGTCGGCGCTGCTGGCCGG
CTGTAACCGGCTTTATTCCGAGGACATGCAGCACGGATTGCTGATCGATCGGCAATTGCGCGTATGCAATCCGTTCATTG
GACCGTCCTGA

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15787.27 Da        Isoelectric Point: 5.2482

>AT185588 WP_054079873.1 NZ_CP067022:c5642698-5642273 [Pseudomonas cannabina pv. alisalensis]
MYQYPLDQHLEPTGVWLSCPDIPEMSASGDTLTEALSEALDGMESALSLYVEQRRKIPQASVVPGHELLMRLPALTVAKI
MLWNSLLEEGVSRAELARRLGCTRQVVYRLVDFLHASKIEQVERALAELGRRITLSIERAA

Download         Length: 426 bp

>AT185588 NZ_CP088923:1725372-1725602 [Rhodanobacter thiooxydans]
ATGCAGGTTTCGAAGTGGGGCAACAGTCTGGCGATTCGCCTGCCCGCCGCGGTGGTCGATGCGCTGCAGCTGCGCGATGG
CGACGACATCGAGGTGCGCGTTGCCGGTGCGCGCGTGTTCGAGGTGAAAAAGGAACCCGGCCGGCAGGAACTGCTGCAGC
GGTTGCGCAAGTTCCGCGGACGGCTTCCCGCAGGTTTCGTGTTCGAGCGTGATGGCGCGCATGAGCGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References