Detailed information of TA system TA185578

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 988052..988855
• Replicon: chromosome
• Accession: NZ_CP067014
• Organism: Staphylococcus pasteuri strain FDAARGOS_1069

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: I6I26_RS04945
• Protein ID: WP_126567444.1
• Coordinates: 988679..988855 (+)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: A0A654BAN2
• Locus tag: I6I26_RS04940
• Protein ID: WP_017638029.1
• Coordinates: 988052..988651 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I26_RS04920	983951..985411	+	1461	WP_126567443.1	ABC transporter substrate-binding protein/permease	-
I6I26_RS04925	985404..986126	+	723	WP_046466853.1	amino acid ABC transporter ATP-binding protein	-
I6I26_RS04930	986269..987399	+	1131	WP_046466852.1	tRNA epoxyqueuosine(34) reductase QueG	-
I6I26_RS04935	987400..987870	+	471	WP_017638028.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
I6I26_RS04940	988052..988651	+	600	WP_017638029.1	glucosamine-6-phosphate isomerase	Antitoxin
I6I26_RS04945	988679..988855	+	177	WP_126567444.1	hypothetical protein	Toxin
I6I26_RS04950	989007..989399	+	393	WP_017638031.1	hypothetical protein	-
I6I26_RS04955	989555..990940	+	1386	WP_046466851.1	class II fumarate hydratase	-
I6I26_RS04960	991000..991830	-	831	WP_126567445.1	RluA family pseudouridine synthase	-
I6I26_RS04965	992008..993120	+	1113	WP_126567446.1	GAF domain-containing sensor histidine kinase	-
I6I26_RS04970	993141..993764	+	624	WP_126567447.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (125-195)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6799.17 Da
• Isoelectric Point: 3.8537

>T185578 WP_126567444.1 NZ_CP067014:988679-988855 [Staphylococcus pasteuri]
MIQNKDSKTNYHEEENAMVTDLDDLKDLGKEMEQISEENDEDKLNQSHDSDVRSDLEE

Nucleotide

• Length: 177 bp

>T185578 NZ_CP088921:722069-722350 [Rhodanobacter denitrificans]
GTGATAAGGAGCTTCGCTGACAAGGAAACCGCGCGACTGTCCGCGACCGGAACAAGCCGGCGGTTTCCGCCGGACATCGT
GCGGCGGGCGCTGAGTCGTCTGAAATATTTGCATCTCGCCACCTGCCCCGAAGATCTGCGCGAGCCGTTTTCCAATCGCC
TGGAAATGTTGAGCGGCAATCGCGCAGGTCAATGGAGTATCCGCATCAACGATCAGTGGCGGCTGTGCTTCCGTTTCGAG
GGCGGCGATGCCTTCGACGTCGAGATCGTCGACTACCATTGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22646.58 Da
• Isoelectric Point: 4.9933

>AT185578 WP_017638029.1 NZ_CP067014:988052-988651 [Staphylococcus pasteuri]
MAMNFKVFEDKQRVAEYTADILRKQFNNNPMTIAGVHLTKDHAPVLDELKKNVELHAVDFSQINILDYDENKSYYEALGV
PQSQIYSLSYNQDANEFISDKIKTKENKGKLVLQVVSIDENGNLDVSVRQGLLEAREIFLVVTGSNKREVVEKLYNENGK
SNYEPADLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT185578 NZ_CP088921:722363-722668 [Rhodanobacter denitrificans]
ATGTCCATCCCCGCCACCACGAACGGCCTGCCGCCCATTCATCCGGGGGAACTCCTGGAAGAAATCCTGTCCGACCACGG
CATGAGCCAGGCGGCATTTGCCCGGGCGATCGGCGTTTCGCCGATGCGTATTTCGCATGTCATCCGCGAGGAGCGCCCCG
TCACGGCCGAACTTGCCCTGCGCTTTGGCCGCGCCTTCGGCCAGAGCCCGCAGTTCTGGATGAACATGCAGACCGACTAC
GACCTCAAGATCGCCGAGCGTGAACTGAAGGCGAGTTTGCGGAAAGTTCTGCCATTGGCGGCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A654BAN2